ArticleProceedings of the National Academy of Sciences of the United States of America2021
The evolution and changing ecology of the African hominid oral microbiome.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68citing papers in PubMed
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68 citing papers in PubMed, 173 citations in OpenAlex.
- Comparing the Performance of Double-Stranded and Single-Stranded DNA Libraries for Ancient Oral Microbiome Reconstruction.Molecular ecology resources · 2026Article
- Lifestyle Impacts the Oral Microbiome of Classical and Post-Classical Societies in Italy.American journal of biological anthropology · 2026Article
- The Oral Microbiome of King Richard III of England.American journal of biological anthropology · 2026Article
- De novo assembly and authentication of ancient DNA metagenomes with nf-core/mag.PLoS computational biology · 2026Article
- Dental Calculus Formation Is Linked to Diet and Phylogeny in Mammals.Ecology and evolution · 2026Article
- Mesopotamian ancient DNA reveals Iron Age integration of heterogeneous Bronze Age genetic ancestries following resettlement.Genome biology · 2026Article
- Insights into demographic and cultural influences on the oral microbiome from historical Japanese dental calculus.Scientific reports · 2026Article
- Genomic evidence for limited entomophagy in ancient Europeans.Science advances · 2026Article
- Ancient Species Diversity and Niche Adaptation in Tannerella and Porphyromonas Revealed Through Pangenomics.Genome biology and evolution · 2026Article
- An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy.Nature communications · 2026Article
- The genomic history of Streptococcus mutans from the Mesolithic until modern times.Genome biology · 2026Article
- Article
- Actifensin Evolution in the Human Oral Cavity over the Past 100,000 Years.Journal of the American Chemical Society · 2025Article
- Archaeogenetics reconstructs demography and extreme parental consanguinity in a Bronze Age community from Southern Italy.Communications biology · 2025Article
- Amylase Binding to Oral Streptococci: A Key Interaction for Human Oral Microbial Ecology, Adaptation and Fitness.Biomolecules · 2025Review
- Host Traits Impact the Outcome of Metagenomic Library Preparation From Dental Calculus Samples Across Diverse Mammals.Molecular ecology resources · 2025Article
- Wet Lab Protocols Matter: Choice of DNA Extraction and Library Preparation Protocols Bias Ancient Oral Microbiome Recovery.Molecular ecology resources · 2025Article
- Comprehensive metagenomic analysis of the giant panda's oral microbiome reveals distinct taxonomic and functional characteristics.Animal microbiome · 2025Article
- CarpeDeam: a de novo metagenome assembler for heavily damaged ancient datasets.Genome biology · 2025Article
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
8 more citing papers are in PubMed but not listed here.
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Authors and funding
49 authors at 20 institutions in 13 countries.
James A Fellows YatesDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany; fellows@shh.mpg.de warinner@shh.mpg.de.ORCID 0000-0001-5585-6277
Irina M VelskoDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.ORCID 0000-0001-9810-9917
Franziska AronDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.
Cosimo PosthDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.
Courtney A HofmanDepartment of Anthropology, University of Oklahoma, Norman, OK 73019.ORCID 0000-0002-6808-3370
Rita M AustinDepartment of Anthropology, University of Oklahoma, Norman, OK 73019.
Cody E ParkerDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.ORCID 0000-0001-5528-4299
Allison E MannDepartment of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107.ORCID 0000-0001-7170-6017
Kathrin NägeleDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.
Kathryn Weedman ArthurDepartment of Anthropology, University of South Florida, St. Petersburg, FL 33701.ORCID 0000-0003-2955-6080
John W ArthurDepartment of Anthropology, University of South Florida, St. Petersburg, FL 33701.ORCID 0000-0002-4968-5843
Catherine C BauerPalaeobiology, Biogeology, Department of Geosciences, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.ORCID 0000-0002-2281-0501
Isabelle CrevecoeurDe la Préhistoire à l'Actuel: Culture, Environnement et Anthropologie (PACEA), CNRS UMR 5199, Université de Bordeaux, 33615 Pessac, France.ORCID 0000-0002-1781-3206
Christophe CupillardLaboratoire Chronoenvironnement, CNRS UMR 6249, 25030 Besançon, France.ORCID 0000-0002-8567-3540
Matthew C CurtisAnthropology Program, California State University Channel Islands, Camarillo, CA 93012.ORCID 0000-0003-4692-3241
Love DalénCentre for Palaeogenetics, 10691 Stockholm, Sweden.ORCID 0000-0001-8270-7613
Marta Díaz-Zorita BonillaInstitut für Ur- und Frühgeschichte und Archäologie des Mittelalters, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.ORCID 0000-0002-1697-0111
J Carlos Díez Fernández-LomanaPrehistoria, Departamento de Historia, Geografía y Comunicación, Universidad de Burgos, 09001 Burgos, Spain.ORCID 0000-0002-3856-1837
Dorothée G DruckerSenckenberg Centre for Human Evolution and Palaeoenviroment, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.
Elena Escribano EscriváEscribano Escrivá Clínica Dental, 38003 Santa Cruz de Tenerife, Spain.
Michael FranckenLandesamt für Denkmalpflege im Regierungspräsidium Stuttgart, 78467 Konstanz, Germany.ORCID 0000-0001-6336-2111
Victoria E GibbonDivision of Clinical Anatomy and Biological Anthropology, Department of Human Biology, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0001-7875-3297
Manuel R González MoralesInstituto Internacional de Investigaciones Prehistóricas de Cantabria, Universidad de Cantabria-Gobierno de Cantabria-Banco, 39071 Santander, Spain.ORCID 0000-0001-7277-7837
Ana Grande MateuClínica Dental Grande Mateu, 46004 València, Spain.
Katerina HarvatiSenckenberg Centre for Human Evolution and Palaeoenviroment, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.
Amanda G HenryFaculty of Archaeology, Leiden University, 2333CC Leiden, The Netherlands.ORCID 0000-0002-2923-4199
Louise HumphreyCentre for Human Evolution Research, The Natural History Museum, London SW7 5BD, United Kingdom.ORCID 0000-0003-3595-0543
Mario MenéndezDepartamento de Prehistòria y Arqueología, Universidad Nacional de Educación, 28040 Madrid, Spain.ORCID 0000-0002-2421-480X
Dušan MihailovićDepartment of Archaeology, Faculty of Philosophy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8607-8196
Marco PeresaniDepartment of Humanities, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-6562-6336
Sofía Rodríguez MoroderClínica Alboraya 10, 46010 València, Spain.
Mirjana RoksandicDepartment of Anthropology, University of Winnipeg, Winnipeg, MB R3T 3C7, Canada.ORCID 0000-0003-0291-6357
Hélène RougierDepartment of Anthropology, California State University, Northridge, CA 91330.ORCID 0000-0003-0358-0285
Sandra SázelováInstitute of Archaeology at Brno, Czech Academy of Sciences, 60200 Brno, Czech Republic.ORCID 0000-0002-7326-8134
Jay T StockDepartment of Anthropology, Western University, London, ON N6A 5C2, Canada.
Lawrence Guy StrausDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.ORCID 0000-0003-0348-3338
Jiří SvobodaInstitute of Archaeology at Brno, Czech Academy of Sciences, 60200 Brno, Czech Republic.ORCID 0000-0003-4256-9708
Barbara TeßmannMuseum für Vor- und Frühgeschichte Berlin, Stiftung Preussischer Kulturbesitz, 10117 Berlin, Germany.ORCID 0000-0002-3122-4707
Michael J WalkerDepartamento de Zoología y Antropología Física, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0003-4359-7436
Robert C PowerInstitute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig-Maximilians-University Münich, 80539 Münich, Germany.ORCID 0000-0001-7425-5709
Cecil M LewisDepartment of Anthropology, University of Oklahoma, Norman, OK 73019.ORCID 0000-0002-2198-3427
Krithivasan SankaranarayananDepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019.
Katerina GuschanskiAnimal Ecology, Department of Ecology and Genetics, Uppsala University, 75236 Uppsala, Sweden.ORCID 0000-0002-8493-5457
Richard W WranghamDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-0435-2209
Floyd E DewhirstDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142.ORCID 0000-0003-4427-7928
Domingo C Salazar-GarcíaDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Johannes KrauseDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.ORCID 0000-0001-9144-3920
Alexander HerbigDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.ORCID 0000-0003-1176-1166
Christina WarinnerDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany; fellows@shh.mpg.de warinner@shh.mpg.de.ORCID 0000-0002-4528-5877
Max Planck Institute for the Science of Human History · DEHarvard University · USUniversity of Oklahoma · USCentre National de la Recherche Scientifique · FRMax Planck Institute for Evolutionary Anthropology · DESenckenberg Centre for Human Evolution and Palaeoenvironment · DEUniversity of South Florida St. Petersburg · USUniversity of Tübingen · DECalifornia State University, Channel Islands · USCalifornia State University, Northridge · USCzech Academy of Sciences, Institute of Archaeology, Brno · CZIkerbasque · ESLeiden University · NLMasaryk University · CZNatural History Museum · GBPrussian Cultural Heritage Foundation · DERegierungspräsidium Stuttgart · DESwedish Museum of Natural History · SEUniversidad de Burgos · ESUniversidad de Cantabria · ES
Funding
Mouse Oral Microbiome DatabaseR37DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E · 2011 to 2020
$8.6MCultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral MicrobiomR01DE024468 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI ALM, ERIC JOHN, DEWHIRST, FLOYD E · 2014 to 2018
$7.3MCloud-Based Machine Learning and Biomarker Visual Analytics for Salivary ProteomicsR01DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E, MARK WELCH, JESSICA LEIGH · 2021 to 2025
$6.7MMicrobial Ecologies of Indigenous CommunitiesR01GM089886 · NIGMS · UNIVERSITY OF OKLAHOMA · PI LAWSON, PAUL ALAN, LEWIS, CECIL M · 2011 to 2019
$2.4MNIDCR NIH HHS R01 DE016937NIDCR NIH HHS R01 DE024468NIDCR NIH HHS R37 DE016937NIGMS NIH HHS R01 GM089886
Abstract
The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine-platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of
Indexed as
Biological EvolutionAfricaAnimalsBacteriaBiofilmsDental PlaqueEcologyGeographyGorilla gorillaHominidaeHumansMetagenomeMicrobiotaMouthPan troglodytesPhylogenydental calculusmicrobiomeNeanderthalprimatesalivary amylase
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