Evidence map›Paper›PMID 33972422›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

TSG101 negatively regulates mitochondrial biogenesis in axons.

Tzu-Huai Lin, Dana M Bis-Brewer, Amy E Sheehan, Louise N Townsend, Daniel C Maddison, Stephan Züchner, Gaynor A Smith, Marc R Freeman

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tzu-Huai LinVollum Institute, Oregon Health & Science University, Portland, OR 97239.ORCID 0000-0001-6549-9971
Dana M Bis-BrewerJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL 33136.
Amy E SheehanVollum Institute, Oregon Health & Science University, Portland, OR 97239.
Louise N TownsendUK Dementia Research Institute, School of Biosciences, Cardiff University, Cardiff CF24 4HQ, United Kingdom.ORCID 0000-0002-6684-544X
Daniel C MaddisonUK Dementia Research Institute, School of Medicine, Cardiff University, Cardiff CF24 4HQ, United Kingdom.ORCID 0000-0003-3038-1687
Stephan ZüchnerJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL 33136.
Gaynor A SmithUK Dementia Research Institute, School of Medicine, Cardiff University, Cardiff CF24 4HQ, United Kingdom smithga@cardiff.ac.uk freemmar@ohsu.edu.ORCID 0000-0003-4332-8383
Marc R FreemanVollum Institute, Oregon Health & Science University, Portland, OR 97239; smithga@cardiff.ac.uk freemmar@ohsu.edu.ORCID 0000-0003-3481-3715
UK Dementia Research Institute · GBVollum Institute · USUniversity of Miami · US

Funding

Molecular Mechanisms of Axon DegenerationR01NS059991 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEMAN, MARC R · 2008 to 2023
$5.4M
Characterizing new genes that govern mitochondrial function in the axonR21NS098364 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEMAN, MARC R · 2016 to 2017
$424k
Medical Research Council MC_PC_16030/1NINDS NIH HHS R01 NS059991NINDS NIH HHS R21 NS098364
6 · The paper itself

Abstract

There is a tight association between mitochondrial dysfunction and neurodegenerative diseases and axons that are particularly vulnerable to degeneration, but how mitochondria are maintained in axons to support their physiology remains poorly defined. In an in vivo forward genetic screen for mutants altering axonal mitochondria, we identified

Indexed as

Organelle BiogenesisAnimalsAnimals, Genetically ModifiedAxonsCytoskeletal ProteinsDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsEndosomal Sorting Complexes Required for TransportFemaleGTP-Binding ProteinsHumansMaleMitochondriaMitochondrial DynamicsMitophagyCytoskeletal ProteinsDNA-Binding ProteinsDrosophila ProteinsDRP1 protein, DrosophilaEndosomal Sorting Complexes Required for TransportGTP-Binding ProteinsNF-E2-Related Factor 2Transcription FactorsTsg101 ProteinESCRTmitochondriamitochondrial biogenesisneurodegenerationTSG101

Identifiers

PMID33972422
PMCPMC8157921
OpenAlexW3161852471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.