Evidence map›Paper›PMID 33972416›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Capsular polysaccharide correlates with immune response to the human gut microbe

Matthew T Henke, Eric M Brown, Chelsi D Cassilly, Hera Vlamakis, Ramnik J Xavier, Jon Clardy

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 120 citations in OpenAlex.

  1. Trial
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  4. Extensive library ofMicrobiology spectrum · 2026
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  9. The Extract ofFood science & nutrition · 2026
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew T HenkeDepartment of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-8325-6420
Eric M BrownDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Chelsi D CassillyDepartment of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-9611-7438
Hera VlamakisDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Ramnik J XavierDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Jon ClardyDepartment of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; jon_clardy@hms.harvard.edu.ORCID 0000-0003-0213-8356
Broad Institute · USHarvard University · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
A comprehensive platform for novel therapy development from the microbiomeR24DK110499 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS · 2017 to 2021
$7.7M
Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopyR01AT009708 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, XAVIER, RAMNIK J · 2017 to 2021
$3.3M
Elucidating the role of an immunomodulator from a gut microbe in inflammatory bowel diseaseF32GM126650 · NIGMS · HARVARD MEDICAL SCHOOL · PI HENKE, MATTHEW THOMAS · 2017 to 2020
$186k
NCCIH NIH HHS R01 AT009708NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R24 DK110499NIGMS NIH HHS F32 GM126650
6 · The paper itself

Abstract

Active inflammatory bowel disease (IBD) often coincides with increases of

Indexed as

AdultAnimalsAnti-Bacterial AgentsBacterial CapsulesCells, CulturedChildCytokinesEubacterialesFemaleGastrointestinal MicrobiomeHumansIleumImmunityInflammatory Bowel DiseasesMiceMice, Inbred C57BLAnti-Bacterial AgentsCytokinesPolysaccharidescapsular polysaccharidecapsuledendritic cellinflammationRuminococcus gnavus

Identifiers

PMID33972416
PMCPMC8157926
OpenAlexW3161010393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.