ArticleDiabetes2021
Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles.
Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Semaglutide Treatment in Young Adults Living With Type 2 Diabetes: A Post Hoc Analysis From the SUSTAIN and PIONEER Clinical Trials.Diabetes, obesity & metabolism · 2026Trial
- Chronotype, Life's Essential 8, and Risk of Cardiovascular Disease: A Prospective Cohort Study in UK Biobank.Journal of the American Heart Association · 2026Article
- Latent class growth mixture modeling of HbA1C trajectories identifies individuals at high risk of developing complications of type 2 diabetes mellitus in the UK Biobank.BMJ open diabetes research & care · 2025Article
- A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.Diabetologia · 2025Article
- Abnormalities of lipid metabolism in the progression and treatment of depression.Frontiers in psychiatry · 2025Review
- Improving T2D machine learning-based prediction accuracy with SNPs and younger age.Computational and structural biotechnology journal · 2025Article
- Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank.Diabetes care · 2024Article
- Young-Onset Diabetes in East Asians: From Epidemiology to Precision Medicine.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study.Journal of epidemiology · 2024Article
- Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity.Human molecular genetics · 2023Article
- The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective.GeroScience · 2023Article
- Four missense genetic variants inFrontiers in endocrinology · 2023Article
- Comprehensive risk profiles of family history and lifestyle and metabolic risk factors in relation to diabetes: A prospective cohort study.Journal of diabetes · 2022Article
- Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization.GeroScience · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we used a stratification based on age of diagnosis to gain insight into the genetics and causal risk factors of T2D across different age-groups. We performed genome-wide association studies (GWAS) on T2D and T2D subgroups based on age of diagnosis (<50, 50-60, 60-70, and >70 years) (total of 24,986 cases). As control subjects, participants were at least 70 years of age at the end of follow-up without developing T2D (
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