Evidence map›Paper›PMID 33972239›Full record

ArticleAntimicrobial agents and chemotherapy2021

Efficacy of Omadacycline against Escherichia coli in a Mouse Urinary Tract Infection Model.

Kavindra V Singh, Barbara E Murray

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kavindra V SinghDivision of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Barbara E MurrayDivision of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · US

Funding

Developing a better understanding of expression and function of PBP5-R of Enterococcus faecium for future development of therapeutic modalities for VRE infectionsR21AI133289 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MURRAY, BARBARA E · 2018 to 2019
$439k
NIAID NIH HHS R21 AI133289
6 · The paper itself

Abstract

In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains.

Indexed as

Escherichia coliUrinary Tract InfectionsAnimalsMiceMicrobial Sensitivity TestsTetracyclinesomadacyclineTetracyclinesEscherichia colimouse UTIomadacycline

Identifiers

PMID33972239
PMCPMC8218671
OpenAlexW3157767715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.