Evidence map›Paper›PMID 33972237›Full record

ArticleAntimicrobial agents and chemotherapy2021

Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri.

Francois Lebreton, Brendan W Corey, Christi L McElheny, Alina Iovleva, Lan Preston, Katie R Margulieux, Robert J Cybulski, Patrick Mc Gann, Yohei Doi, Jason W Bennett

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Clinical microbiology reviews · 2023
    Review
  6. A brief insight intoFrontiers in antibiotics · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Francois Lebreton *Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Brendan W Corey *Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Christi L McElhenyDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Alina IovlevaDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lan PrestonMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Katie R MargulieuxMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Robert J CybulskiDepartment of Pathology and Laboratory Services, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, Texas, USA.
Patrick Mc GannMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Yohei DoiDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jason W BennettMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Walter Reed Army Institute of Research · USUniversity of Pittsburgh · USBrooke Army Medical Center · US

Funding

Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
VIROLOGY AND IMMUNOLOGY OF ACUTE HIV1 INFECTIONR01AI035522 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI PETERSON, DOLORES MURL · 1994 to 2006
$2.7M
Mechanisms of cefiderocol resistanceR21AI151362 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2020 to 2021
$420k
VIROLOGY AND IMMUNOLOGY OF ACUTE HIV1 INFECTIONR37AI035522 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KOUP, RICHARD A. · 1998 to 2000
$373k
NIAID NIH HHS R01 AI035522NIAID NIH HHS R01 AI104895NIAID NIH HHS R21 AI151362NIAID NIH HHS R37 AI035522Wellcome Trust
6 · The paper itself

Abstract

KPC-82 is a KPC-2 variant identified in a carbapenem-nonsusceptible Citrobacter koseri that confers high-level resistance to ceftazidime-avibactam. Genomic analysis revealed that

Indexed as

CarbapenemsCitrobacter koseriAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeDrug CombinationsKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCarbapenemsCeftazidimeDrug Combinationscarbapenemsceftazidime-avibactamCitrobacter koseriCREKPC

Identifiers

PMID33972237
PMCPMC8218621
OpenAlexW3159526512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.