Evidence map›Paper›PMID 33972197›Full record

ArticleTrends in cancer2021

Translational Control of Immune Evasion in Cancer.

Shruthy Suresh, Kathryn A O'Donnell

Open access · hybridAbstract read
In one paragraph

Article in Trends in cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Immunogenic cell stress and death.Nature immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Shruthy SureshDepartment of Molecular Biology, University of Texas Southwestern (UTSW) Medical Center, Dallas, TX 75390, USA.
Kathryn A O'DonnellDepartment of Molecular Biology, University of Texas Southwestern (UTSW) Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, UTSW Medical Center, Dallas, TX 75390, USA. Electronic address: Kathryn.ODonnell@UTSouthwestern.edu.
Harold C. Simmons Comprehensive Cancer CenterThe University of Texas Southwestern Medical Center · US

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4M
The role of PCDH7 in lung cancer pathogenesisR01CA207763 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI O'DONNELL, KATHRYN ANN · 2017 to 2021
$2.0M
The role of translation initiation factor eIF5B in lung cancer pathogenesisR01CA273585 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2023 to 2026
$1.9M
NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA207763NCI NIH HHS R01 CA273585
6 · The paper itself

Abstract

Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control of immune checkpoints and implications for cancer immunotherapies.

Indexed as

Disease ProgressionEukaryotic Initiation FactorsGene Expression Regulation, NeoplasticHumansImmune Checkpoint InhibitorsImmune Checkpoint ProteinsNeoplasmsProtein BiosynthesisTumor EscapeEukaryotic Initiation FactorsImmune Checkpoint InhibitorsImmune Checkpoint Proteinsalternative translation initiation factorsimmune checkpointsintegrated stress response (ISR) pathwayPD-1/PD-L1translation regulation

Identifiers

PMID33972197
PMCPMC8262573
OpenAlexW3162273457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.