Evidence map›Paper›PMID 33972153›Full record

ArticleUltrasound in medicine & biology2021

The Influence of Xylazine and Clonidine on Lung Ultrasound-Induced Pulmonary Capillary Hemorrhage in Spontaneously Hypertensive Rats.

Douglas L Miller, Chunyan Dou, Krishnan Raghavendran, Zhihong Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Douglas L MillerDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA. Electronic address: douglm@umich.edu.
Chunyan DouDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Krishnan RaghavendranDepartment of Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA.
Zhihong DongDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.

Funding

Ultrasound-Induced Pulmonary Hemorrhage During Diagnostic Examination of the LungR01HL116434 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, DOUGLAS LAWRENCE · 2013 to 2021
$4.2M
NHLBI NIH HHS R01 HL116434
6 · The paper itself

Abstract

Induction of pulmonary capillary hemorrhage (PCH) by lung ultrasound (LUS) depends not only on physical exposure parameters but also on physiologic conditions and drug treatment. We studied the influence of xylazine and clonidine on LUS-induced PCH in spontaneously hypertensive and normotensive rats using diagnostic B-mode ultrasound at 7.3 MHz. Using ketamine anesthesia, rats receiving saline, xylazine, or clonidine treatment were tested with different pulse peak rarefactional pressure amplitudes in 5 min exposures. Results with xylazine or clonidine in spontaneously hypertensive rats were not significantly different at the three exposure pulse peak rarefactional pressure amplitudes, and thresholds were lower (2.2 MPa) than with saline (2.6 MPa). Variations in LUS PCH were not correlated with mean systemic blood pressure. Similar to previous findings for dexmedetomidine, the clinical drug clonidine tended to increase susceptibility to LUS PCH.

Indexed as

CapillariesAnimalsAntihypertensive AgentsClonidineHemorrhageHypertensionLungMaleRatsRats, Inbred SHRRats, Inbred WKYUltrasonic WavesUltrasonographyXylazineAntihypertensive AgentsClonidineXylazineBioeffects of ultrasoundB-linesDiagnostic ultrasound safetyLung ultrasoundPoint-of-care ultrasoundUltrasound dosimetry

Identifiers

PMID33972153
PMCPMC8243848

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.