ArticleBiotechnology for biofuels2021
Synergistic mechanism of GH11 xylanases with different action modes from Aspergillus niger An76.
Article in Biotechnology for biofuels, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 29 citations in OpenAlex.
- Whole-genome analysis and enzymatic profiling of Bacillus spizizenii as a xylanase-producing source from Iran.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Temporal Variation in Mechanical and Chemical Properties of Bamboo Decayed byJournal of fungi (Basel, Switzerland) · 2026Article
- Utilisation of mango seed husk for the production of phenolic compounds and glucose with C1184 enzyme preparation reveals the role of glucuronoyl esters in lignin-carbohydrate linkages in biomass recalcitrance.Bioresources and bioprocessing · 2025Article
- Harnessing Xylanase Potential inJournal of fungi (Basel, Switzerland) · 2025Article
- Harnessing Filamentous Fungi for Enzyme Cocktail Production Through Rice Bran Bioprocessing.Journal of fungi (Basel, Switzerland) · 2025Article
- Expression inInternational journal of molecular sciences · 2024Article
- Temporal Dynamics of Fungal Communities in Alkali-Treated Round Bamboo Deterioration under Natural Weathering.Microorganisms · 2024Article
- Discovery of novel alkaline-tolerant xylanases from fecal microbiota of dairy cows.Biotechnology for biofuels and bioproducts · 2023Article
- Yeasts Have Evolved Divergent Enzyme Strategies To Deconstruct and Metabolize Xylan.Microbiology spectrum · 2023Article
- Optimization, purification, and characterization of xylanase production by a newly isolated Trichoderma harzianum strain by a two-step statistical experimental design strategy.Scientific reports · 2022Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundXylan is the most abundant hemicellulose polysaccharide in nature, which can be converted into high value-added products. However, its recalcitrance to breakdown requires the synergistic action of multiple enzymes. Aspergillus niger, possessing numerous xylan degrading isozyme-encoding genes, are highly effective xylan degraders in xylan-rich habitats. Therefore, it is necessary to explore gene transcription, the mode of action and cooperation mechanism of different xylanase isozymes to further understand the efficient xylan-degradation by A. niger.
resultsAspergillus niger An76 encoded a comprehensive set of xylan-degrading enzymes, including five endo-xylanases (one GH10 and four GH11). Quantitative transcriptional analysis showed that three xylanase genes (xynA, xynB and xynC) were up-regulated by xylan substrates, and the order and amount of enzyme secretion differed. Specifically, GH11 xylanases XynA and XynB were initially secreted successively, followed by GH10 xylanase XynC. Biochemical analyses displayed that three GH11 xylanases (XynA, XynB and XynD) showed differences in catalytic performance and product profiles, possibly because of intricate hydrogen bonding between substrates and functional residues in the active site architectures impacted their binding capacity. Among these, XynB had the best performance in the degradation of xylan and XynE had no catalytic activity. Furthermore, XynA and XynB showed synergistic effects during xylan degradation.
conclusionsThe sequential secretion and different action modes of GH11 xylanases were essential for the efficient xylan degradation by A. niger An76. The elucidation of the degradation mechanisms of these xylanase isozymes further improved our understanding of GH-encoding genes amplification in filamentous fungi and may guide the design of the optimal enzyme cocktails in industrial applications.
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