Evidence map›Paper›PMID 33971949›Full record

SynthesisSystematic reviews2021

AGREEing on clinical practice guidelines for idiopathic steroid-sensitive nephrotic syndrome in children.

Khalid Abdulaziz Alhasan, Reem Al Khalifah, Majed Aloufi, Weiam Almaiman, Muddathir Hamad, Naif Abdulmajeed, Abdullah Al Salloum, Jameela A Kari, Muneera AlJelaify, Rolan K Bassrawi and 9 more

Abstract readSystematic Review
In one paragraph

Synthesis in Systematic reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Khalid Abdulaziz AlhasanPediatric Nephrology Unit, Pediatrics Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Reem Al KhalifahPediatric Endocrinology Unit, Pediatrics Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Majed AloufiDepartment of Pediatric Nephrology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Weiam AlmaimanCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Muddathir HamadPediatric Neurology Unit, Pediatrics Department, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Naif AbdulmajeedPrince Sultan Military Medical City, Riyadh, Saudi Arabia.
Abdullah Al SalloumPediatric Nephrology Unit, Pediatrics Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Jameela A KariPediatric Nephrology Division, Department of Pediatrics, Pediatric Nephrology Center of Excellence Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Muneera AlJelaifyPharmacy Services Department, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Rolan K BassrawiGeneral Pediatrics Unit, Pediatrics Department, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Turki Al HussainCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Adi AlherbishPediatrics Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Abdulhadi Al TalhiDepartment of Pediatric Nephrology, Pediatrics Hospital, King Saud Medical City, Riyadh, Saudi Arabia.
Mohamad-Hani TemsahPediatric Intensive Care Unit, Pediatric Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Sidharth Kumar SethiPediatric Nephrology, Medanta, The Medicity, Gurgaon, India.
Rupesh RainaPediatric Nephrology, Akron Children's Hospital, Akron, OH, USA.
Reny JosephWard 11B and Day Care, Pediatrics-Nursing, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Yasser Sami AmerPediatrics Department, King Khalid University Hospital, Riyadh, Saudi Arabia. yamer@ksu.edu.sa.ORCID 0000-0003-4097-2317
Saudi Society of Nephrology and Transplantation

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNephrotic syndrome is the most common kidney disease in children worldwide. Our aim was to critically appraise the quality of recent Clinical Practice Guidelines (CPGs) for idiopathic steroid-sensitive nephrotic syndrome (SSNS) in children in addition to summarize and compare their recommendations.

methodsSystematic review of CPGs. We identified clinical questions and eligibility criteria and searched and screened for CPGs using bibliographic and CPG databases. Each included CPG was assessed by four independent appraisers using the Appraisal of Guidelines for REsearch & Evaluation II (AGREE-II) instrument. We summarized the recommendations in a comparison practical table.

resultsOur search retrieved 282 citations, of which three CPGs were eligible and appraised: Kidney Disease: Improving Global Outcomes (KDIGO) 2012, Japan Society for Pediatric Nephrology (JSPN) 2014, and American Academy of Pediatrics (AAP) 2009. Among these, the overall assessment of two evidence-based CPGs scored > 70% (KDIGO and JSPN), which was consistent with their higher scores in the six domains of the AGREE II Instrument. In domain 3 (rigor of development), KDIGO, JSPN, and AAP scored 84%, 74%, and 41%, respectively. In domain 5 (applicability), they scored 22%, 16%, and 19%, respectively, and in domain 6 (editorial independence), they scored 94%, 65%, and 88%, respectively.

conclusionsThe methodological quality of the KDIGO CPG was superior, followed by JSPN and AAP CPGs with the relevant recommendations for use in practice. SYSTEMATIC REVIEW REGISTRATION: The protocol was registered in the Center for Open Science (OSF) DOI: 10.17605/OSF.IO/6QTMD and in the International prospective register of systematic reviews PROSPERO 2020 CRD42020197511 .

Indexed as

Nephrotic SyndromeChildDatabases, FactualEvidence-Based PracticeHumansPractice Guidelines as TopicSteroidsSteroidsAGREE II InstrumentClinical practice guidelinesNephrotic syndromePediatricsQuality assessmentSystematic review

Identifiers

PMID33971949
PMCPMC8112064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.