Evidence map›Paper›PMID 33971936›Full record

ReviewInfectious agents and cancer2021

Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection.

Maria Isaguliants, Stepan Krasnyak, Olga Smirnova, Vincenza Colonna, Oleg Apolikhin, Franco M Buonaguro

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Infectious agents and cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. HPV-related diseases in male patients: an underestimated conundrum.Journal of endocrinological investigation · 2024
    Review
  11. Human Papillomavirus and Male Infertility: What Do We Know?International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 5 countries.

Maria IsaguliantsN.F. Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia. maria.issagouliantis@ki.se.ORCID http://orcid.org/0000-0001-9382-2254
Stepan KrasnyakResearch Institute of Urology and Interventional Radiology named after N.A. Lopatkin, Moscow, Russia.
Olga SmirnovaN.F. Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia.
Vincenza ColonnaInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso", National Research Council, Naples, Italy.
Oleg ApolikhinResearch Institute of Urology and Interventional Radiology named after N.A. Lopatkin, Moscow, Russia.
Franco M BuonaguroIstituto Nazionale Tumori - IRCCS "Fondazione Pascale", Naples, Italy.
Engelhardt Institute of Molecular Biology · RUInstitute of Genetics and Biophysics · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITKarolinska Institutet · SE

Funding

Ministry of Science and Higher Education (RU) No. 075-15-2019-1660Russian Fund for Basic Research 17-54-30002
6 · The paper itself

Abstract

Human papillomavirus (HPV) is a sexually transmitted infection common among men and women of reproductive age worldwide. HPV viruses are associated with epithelial lesions and cancers. HPV infections have been shown to be significantly associated with many adverse effects in reproductive function. Infection with HPVs, specifically of high-oncogenic risk types (HR HPVs), affects different stages of human reproduction, resulting in a series of adverse outcomes: 1) reduction of male fertility (male infertility), characterized by qualitative and quantitative semen alterations; 2) impairment of couple fertility with increase of blastocyst apoptosis and reduction of endometrial implantation of trophoblastic cells; 3) defects of embryos and fetal development, with increase of spontaneous abortion and spontaneous preterm birth. The actual molecular mechanism(s) by which HPV infection is involved remain unclear. HPV-associated infertility as Janus, has two faces: one reflecting anti-HPV immunity, and the other, direct pathogenic effects of HPVs, specifically, of HR HPVs on the infected/HPV-replicating cells. Adverse effects observed for HR HPVs differ depending on the genotype of infecting virus, reflecting differential response of the host immune system as well as functional differences between HPVs and their individual proteins/antigens, including their ability to induce genetic instability/DNA damage. Review summarizes HPV involvement in all reproductive stages, evaluate the adverse role(s) played by HPVs, and identifies mechanisms of viral pathogenicity, common as well as specific for each stage of the reproduction process.

Indexed as

DNA damageGastrulationGenomic instabilityHuman papilloma viruses of high oncogenic risk typeInfertilityOocyteReproductive healthSperm cellsSpontaneous abortionViral integration

Identifiers

PMID33971936
PMCPMC8111735
OpenAlexW3160263301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.