ArticleGenome biology2021
The genetic mechanism of heterosis utilization in maize improvement.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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77 citing papers in PubMed, 153 citations in OpenAlex.
- Genetic Dissection of Wheat Heterosis Identifies Candidate Genes in Biparental and Diverse Hybrid Populations.Plant biotechnology journal · 2026Article
- Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.Nature genetics · 2026Article
- Dynamics of Gene and Allelic Expression During Modern Hybrid Maize Breeding.Plant biotechnology journal · 2026Article
- The incomplete dominance of gene expression controlled by Trans-eQTL hotspots contributes to heterosis in maize.Nature communications · 2026Article
- A novel genetic framework reveals transcriptional "butterfly effect" underlying heterosis in maize.Journal of advanced research · 2026Article
- Chromatin accessibility landscape and its association with heterosis in maize hybrids.Nature communications · 2026Article
- Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- MeNet: A mixed-effect deep neural network for multi-environment genomic prediction of agronomic traits.Plant communications · 2026Article
- Genetic dynamics drive maize growth and breeding.Genome biology · 2026Article
- Genomic insights intoFrontiers in plant science · 2026Article
- FFrontiers in plant science · 2026Review
- Genetic characterization of commercial spring maize germplasm in Northern China for hybrid breeding and trait improvement.Frontiers in plant science · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Quantitative Insights into the Genetic Mechanisms of Crop Heterosis.Advanced genetics (Hoboken, N.J.) · 2025Review
- Using transcriptome analysis and QTL mapping to decipher the genetic basis of heterosis in potato root system.BMC plant biology · 2025Article
- Advanced biometrical strategies for genetic analysis and heterosis assessment in maize germplasm.BMC plant biology · 2025Article
- Conservation and variability of long-range interactions in structurally diverse maize genomes.Nature communications · 2025Article
- Six-gene model underlying heterosis for culm length and flowering date in sorghum (Sorghum bicolor (L.) Moench).Scientific reports · 2025Article
- Powerful one-dimensional scan to detect heterotic quantitative trait loci.Nature communications · 2025Article
- Hybrids reveal accessible chromatinbioRxiv : the preprint server for biology · 2025Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn maize hybrid breeding, complementary pools of parental lines with reshuffled genetic variants are established for superior hybrid performance. To comprehensively decipher the genetics of heterosis, we present a new design of multiple linked F1 populations with 42,840 F1 maize hybrids, generated by crossing a synthetic population of 1428 maternal lines with 30 elite testers from diverse genetic backgrounds and phenotyped for agronomic traits.
resultsWe show that, although yield heterosis is correlated with the widespread, minor-effect epistatic QTLs, it may be resulted from a few major-effect additive and dominant QTLs in early developmental stages. Floral transition is probably one critical stage for heterosis formation, in which epistatic QTLs are activated by paternal contributions of alleles that counteract the recessive, deleterious maternal alleles. These deleterious alleles, while rare, epistatically repress other favorable QTLs. We demonstrate this with one example, showing that Brachytic2 represses the Ubiquitin3 locus in the maternal lines; in hybrids, the paternal allele alleviates this repression, which in turn recovers the height of the plant and enhances the weight of the ear. Finally, we propose a molecular design breeding by manipulating key genes underlying the transition from vegetative-to-reproductive growth.
conclusionThe new population design is used to dissect the genetic basis of heterosis which accelerates maize molecular design breeding by diminishing deleterious epistatic interactions.
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