Observational studyRespiratory research2021
Lung function trajectories in children with post-prematurity respiratory disease: identifying risk factors for abnormal growth.
Observational study in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00951366 (Preterm Lung Patient Registry), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preterm Lung Patient Registry
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Newborn blood DNA methylation and childhood asthma: findings from the ECHO program.International journal of epidemiology · 2025Pooled it
- Impaired lung function and associated risk factors in children born prematurely: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Healthcare journey of preterm-born adults with respiratory disease: the EMPOWER survey.ERJ open research · 2026Article
- Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report.The Journal of allergy and clinical immunology · 2026Article
- Article
- Lung Function Trajectories After Preterm Birth: A Life-Course Approach to Age-Specific Monitoring.Children (Basel, Switzerland) · 2026Review
- Optimized primary organotypic culture from murine neonatal tracheal airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Long-term pulmonary outcomes in BPD throughout the life-course.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- The Developmental Origins of Asthma and COPD.Annual review of physiology · 2026Review
- Bronchopulmonary dysplasia into adulthood - lower peak, faster decline?Pediatric research · 2026Article
- Neonatal bronchopulmonary dysplasia severity and respiratory outcomes at 3 years of age: a prospective cohort study.Frontiers in pediatrics · 2026Article
- Development of the Respiratory System During Adolescence.Advances in experimental medicine and biology · 2026Review
- Longitudinal developmental trajectories of weight-standardized lung function in preterm (28-36 + 6 weeks) vs. term infants and independent perinatal risk factors: a single-center prospective cohort study.Frontiers in pediatrics · 2026Article
- Predictors of Bronchodilator Response on Oscillometry and Spirometry in School-Age Children With Bronchopulmonary Dysplasia.Pediatric pulmonology · 2025Observational
- Risk Factors for Severe Respiratory Morbidity at 2 Years of Life in Children Born Extremely Preterm With Bronchopulmonary Dysplasia.Pediatric pulmonology · 2025Article
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Is it time to end race and ethnicity adjustment for pediatric pulmonary function tests?Pediatric pulmonology · 2024Review
- Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age.Pediatric pulmonology · 2024Article
- Article
- The association of the room air challenge with long-term outcomes in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSurvivors of prematurity are at risk for abnormal childhood lung function. Few studies have addressed trajectories of lung function and risk factors for abnormal growth in childhood. This study aims to describe changes in lung function in a contemporary cohort of children born preterm followed longitudinally in pulmonary clinic for post-prematurity respiratory disease and to assess maternal and neonatal risk factors associated with decreased lung function trajectories.
methodsObservational cohort of 164 children born preterm ≤ 32 weeks gestation followed in pulmonary clinic at Boston Children's Hospital with pulmonary function testing. We collected demographics and neonatal history. We used multivariable linear regression to identify the impact of neonatal and maternal risk factors on lung function trajectories in childhood.
resultsWe identified 264 studies from 82 subjects with acceptable longitudinal FEV
conclusionsChildren with post-prematurity respiratory disease demonstrate worsening obstruction in lung function throughout childhood. Neonatal risk factors including exposure to mechanical ventilation and postnatal steroids, as well as maternal atopy and asthma, were associated with diminished rate of rise in lung function. These results may have implications for lung function trajectories into adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.