Evidence map›Paper›PMID 33971876›Full record

ArticleBMC musculoskeletal disorders2021

Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain.

Demario S Overstreet, Ava N Michl, Terence M Penn, Deanna D Rumble, Edwin N Aroke, Andrew M Sims, Annabel L King, Fariha N Hasan, Tammie L Quinn, D Leann Long and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05569486 (Elucidating the Central Mechanism), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05569486 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Elucidating the Central Mechanism(s) of Action for Green Light Therapy in Managing Chronic Pain

TypeinterventionalSponsorUniversity of ArizonaRan2026 to 2029Enrolled70ConditionsFibromyalgiaArmsGreen Light
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Observational
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  4. Review
  5. Article
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  7. Observational
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  9. Article
  10. Review
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  17. A Brief Overview: Sex Differences in Prevalent Chronic Musculoskeletal Conditions.International journal of environmental research and public health · 2023
    Article
  18. Article
  19. Review
  20. Sex Differences in Pain and Its Treatment.Handbook of experimental pharmacology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Demario S OverstreetDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Ava N MichlDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Terence M PennDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Deanna D RumbleDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Edwin N ArokeSchool of Nursing, Nurse Anesthesia Program, Department of Acute, Chronic, & Continuing Care, University of Alabama at Birmingham, Birmingham, USA.
Andrew M SimsSchool of Public Health, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, USA.
Annabel L KingDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Fariha N HasanDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Tammie L QuinnDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
D Leann LongSchool of Public Health, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, USA.
Robert E SorgeDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA.
Burel R GoodinDepartment of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall, Suite 237, Birmingham, AL, 35294, USA. bgoodin1@uab.edu.
University of Alabama at Birmingham · US

Funding

UAB Health Services Research (HSR) Training ProgramT32HS013852 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVITAN, EMILY B, MUGAVERO, MICHAEL J · 2003 to 2024
$8.0M
Racial and Socioeconomic Differences in Chronic Low Back PainR01MD010441 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOODIN, BUREL R., SORGE, ROBERT · 2017 to 2021
$2.6M
AHRQ HHS T32 HS013852NIMHD NIH HHS R01 MD010441
6 · The paper itself

Abstract

backgroundBiopsychosocial factors above and beyond pathoanatomical changes likely contribute to the severity of chronic low back pain. A pro-nociceptive endogenous pain modulatory balance (↓inhibition and ↑facilitation) may be an important contributor to chronic low back pain severity and physical function; however, additional research is needed to address this possibility. The objective of this study was to determine whether quantitative sensory tests of endogenous pain inhibition and facilitation prospectively predict movement-evoked pain and cLBP severity self-reported on a validated questionnaire.

methodsOne hundred thirty-four individuals with chronic low back pain were enrolled in this two-session study. During the first study session, temporal summation of mechanical pain and conditioned pain modulation were assessed at the lumbar spine to determine endogenous pain facilitation and inhibition, respectively. One week later, participants returned for a second study session whereby they reported their pain severity and pain interference using the Brief Pain Inventory-Short Form. Movement-evoked pain and physical function capacity were assessed upon completion of the balance, walking, and transition from sit to stand tests of the Short Physical Performance Battery.

resultsTemporal summation of mechanical pain, but not conditioned pain modulation, significantly and prospectively predicted greater movement-evoked pain and poorer physical function on the Short Physical Performance Battery. Neither temporal summation nor conditioned pain modulation were significantly related to self-reported pain severity or pain interference on the Brief Pain Inventory-Short Form.

conclusionsFindings suggest that a pro-nociceptive pain modulatory balance characterized by enhanced pain facilitation may be an important driver of movement-evoked pain severity and poor physical function in individuals with chronic low back pain.

Indexed as

Chronic PainLow Back PainAdultHumansLumbar VertebraeMovementPain MeasurementPain ThresholdSurveys and QuestionnairesConditioned pain modulationLow back painMovementTemporal summation

Identifiers

PMID33971876
PMCPMC8111750
OpenAlexW3163650769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.