Evidence map›Paper›PMID 33971521›Full record

ArticleJournal of inorganic biochemistry2021

Pyridine-containing octadentate ligand NE3TA-PY for formation of neutral complex with

Hyun-Soon Chong, Yunwei Chen, Chi Soo Kang, Inseok Sin, Shuyuan Zhang, Haixing Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hyun-Soon ChongDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America. Electronic address: chong@iit.edu.
Yunwei ChenDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America.
Chi Soo KangDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America.
Inseok SinDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America.
Shuyuan ZhangDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America.
Haixing WangDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America.
Illinois Institute of Technology · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
New Bifunctional Ligands for RadioimmunotherapyR01CA112503 · NCI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI CHONG, HYUN-SOON · 2006 to 2017
$2.0M
NCI NIH HHS R01 CA112503NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Targeted radionuclide therapy is a developing therapeutic modality for cancer and employs a cytotoxic radionuclide bound to a chelating agent and a bioactive molecule with high binding affinity for a specific biomarker in tumors. An optimal chelator is one of the critical components to control therapeutic efficacy and toxicity of targeted radionuclide therapy. We designed a new octadentate ligand NE3TA-PY (7-[2-[(carboxymethyl)(2-pyridylmethyl)amino]ethyl]-1,4,7-triazacyclononane-1,4-diacetic acid) for β-particle-emitting

Indexed as

Chelating AgentsCoordination ComplexesDensity Functional TheoryDrug StabilityHumansIsotope LabelingLigandsLutetiumModels, ChemicalPyridinesRadioisotopesRadiopharmaceuticalsYttrium RadioisotopesChelating AgentsCoordination ComplexesLigandsLutetiumLutetium-177PyridinesRadioisotopesRadiopharmaceuticalsYttrium-90Yttrium Radioisotopes(90)YChelating agentDFT calculationLu-177NE3TA-PYRadiolabeling

Identifiers

PMID33971521
PMCPMC8344049
OpenAlexW3159228375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.