Evidence map›Paper›PMID 33971376›Full record

ReviewJournal of the neurological sciences2021

Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease.

Elliot M Frohman, Nicole R Villemarette-Pittman, Adriana Rodriguez, Robert Glanzman, Sarah Rugheimer, Oleg Komogortsev, Scott S Zamvil, Roberto Alejandro Cruz, Thomas C Varkey, Ashley N Frohman and 4 more

Abstract readReview
In one paragraph

Review in Journal of the neurological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elliot M FrohmanLaboratory of Neuroimmunology, Professor Lawrence Steinman, Stanford University School of Medicine, United States of America. Electronic address: Elliot.frohman@utexas.edu.
Nicole R Villemarette-PittmanDepartment of Neurology, LSU Health Sciences Center New Orleans, Louisiana, United States of America. Electronic address: nville@lsuhsc.edu.
Adriana RodriguezDepartment of Emergency Medicine, Cook Children's Medical Center, Ft. Worth, TX, United States of America.
Robert GlanzmanClene Nanomedicine, Inc., Salt Lake City, UT 84121, United States of America. Electronic address: robert@clene.com.
Sarah RugheimerDepartment of Physics, University Oxford, Oxford OX1 3PU, UK. Electronic address: sarah.rugheimer@physics.ox.ac.uk.
Oleg KomogortsevDepartment of Computer Sciences, Texas State University, San Marcos, TX, United States of America. Electronic address: ok11@txstate.edu.
Scott S ZamvilDepartment of Neurology and Program in Immunology, University of California San Francisco, San Francisco, CA, United States of America. Electronic address: zamvil@ucsf.neuroimmunol.org.
Roberto Alejandro CruzDepartment of Neurology, Doctor's Health at Renaissance Health Neurology Institute, United States of America; Department of Neurology, University of Texas Rio Grande Valley School of Medicine, United States of America. Electronic address: roberto.cruzsaldana@austin.utexas.edu.
Thomas C VarkeyDell Medical School, University of Texas at Austin, United States of America. Electronic address: tvarkey@utexas.edu.
Ashley N FrohmanThe Frohman Foundation, Austin, TX, United States of America. Electronic address: ash21375019@yahoo.com.
Audrey R FrohmanThe Frohman Foundation, Austin, TX, United States of America. Electronic address: frohman.audrey@yahoo.com.
Matthew S ParsonsDivision of Microbiology and Immunology, Yerkes National Primate Research Center, United States of America; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States of America. Electronic address: matthew.s.parsons@emory.edu.
Emily Heckmann KonkleThe Frohman Foundation, Austin, TX, United States of America. Electronic address: emily@digitalknowledge.net.
Teresa C FrohmanLaboratory of Neuroimmunology, Professor Lawrence Steinman, Stanford University School of Medicine, United States of America. Electronic address: teresafrohmanCOVID@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of our human physiology's most important and vulnerable life-preserving body tissues, our broncho-alveolar gas exchange apparatus. Notwithstanding the fear and the fury of this microbe's potential to raise existential questions across the entire spectrum of human endeavor, the application of an early treatment intervention initiative may represent a crucial tool in our defensive strategy. This strategy is driven by evidence-based medical practice principles, those not likely to become antiquated, given the molecular diversity and mutational evolution of this very clever "world traveler".

Indexed as

COVID-19HumansOutpatientsPandemicsSARS-CoV-2AlveoliBronchioleBudesonideCOVID-19DexamethasoneExpectorateGas exchangeInflammationL-albuterolMethotrexateMucus clearanceOxygen saturationPostural percussionPulmonary hygienePulse oximetryRespiratory muscle trainingSARS-CoV-2Vibratory sonicationVitamin D

Identifiers

PMID33971376
PMCPMC8055502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.