Evidence map›Paper›PMID 33971314›Full record

ReviewBone2021

Suppression of cancer-associated bone loss through dynamic mechanical loading.

G M Pagnotti, W R Thompson, T A Guise, C T Rubin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

G M PagnottiUniversity of Texas - MD Anderson Cancer Center, Department of Endocrine, Neoplasia and Hormonal Disorders, Houston, TX, USA. Electronic address: gmpagnotti@mdanderson.org.
W R ThompsonIndiana University, Department of Physical Therapy, Indianapolis, IN, USA.
T A GuiseUniversity of Texas - MD Anderson Cancer Center, Department of Endocrine, Neoplasia and Hormonal Disorders, Houston, TX, USA.
C T RubinStony Brook University, Department of Biomedical Engineering, Stony Brook, NY, USA.
The University of Texas MD Anderson Cancer Center · USIndiana University – Purdue University Indianapolis · USStony Brook University · US

Funding

Osteocyte Mechanotransduction and the Gabapentin-Sensitive Matrix-Channel Tethering ComplexR01AR074473 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI THOMPSON, WILLIAM ROY · 2018 to 2023
$2.8M
AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAINR01AR043498 · NIAMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI RUBIN, CLINTON T · 1997 to 2012
$2.8M
Harnessing mechanical signals to control mesenchymal stem cell fateR01EB014351 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI JUDEX, STEFAN, RUBIN, CLINTON T · 2012 to 2014
$1.0M
NIAMS NIH HHS R01 AR043498NIAMS NIH HHS R01 AR074473NIBIB NIH HHS R01 EB014351
6 · The paper itself

Abstract

Patients afflicted with or being treated for cancer constitute a distinct and alarming subpopulation who exhibit elevated fracture risk and heightened susceptibility to developing secondary osteoporosis. Cancer cells uncouple the regulatory processes central for the adequate regulation of musculoskeletal tissue. Systemically taxing treatments to target tumors or disrupt the molecular elements driving tumor growth place considerable strain on recovery efforts. Skeletal tissue is inherently sensitive to mechanical forces, therefore attention to exercise and mechanical loading as non-pharmacological means to preserve bone during treatment and in post-treatment rehabilitative efforts have been topics of recent focus. This review discusses the dysregulation that cancers and the ensuing metabolic dysfunction that confer adverse effects on musculoskeletal tissues. Additionally, we describe foundational mechanotransduction pathways and the mechanisms by which they influence both musculoskeletal and cancerous cells. Functional and biological implications of mechanical loading at the tissue and cellular levels will be discussed, highlighting the current understanding in the field. Herein, in vitro, translational, and clinical data are summarized to consider the positive impact of exercise and low magnitude mechanical loading on tumor-bearing skeletal tissue.

Indexed as

Bone Diseases, MetabolicNeoplasmsOsteoporosisBone and BonesHumansMechanotransduction, CellularStress, MechanicalBone remodelingBreast cancer bone metastasesCancer-associated bone diseaseLow intensity vibrationsLow magnitude mechanical signalsMechanical loadingMultiple myelomaOsteolytic lesions

Identifiers

PMID33971314
PMCPMC10044486
OpenAlexW3162593175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.