Evidence map›Paper›PMID 33971138›Full record

ArticleChemistry and physics of lipids2021

Ceramide-mediation of diffusion in supported lipid bilayers.

Masroor Hossain, G J Blanchard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry and physics of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Serotonin Signaling through Lipid Membranes.ACS chemical neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Masroor HossainMichigan State University, Department of Chemistry, 578 S. Shaw Lane, East Lansing, MI, 48824, USA.
G J BlanchardMichigan State University, Department of Chemistry, 578 S. Shaw Lane, East Lansing, MI, 48824, USA. Electronic address: blanchard@chemistry.msu.edu.

Funding

Dyslipidemia and Diabetic RetinopathyR01EY016077 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BUSIK, JULIA V · 2005 to 2025
$6.3M
LXR as a Novel Therapeutic Target in Diabetic RetinopathyR01EY025383 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUSIK, JULIA V, GRANT, MARIA BARTOLOMEO · 2015 to 2024
$4.2M
Anti-ceramide immunotherapy for diabetic retinopathyR01EY030766 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Julia V Busik, Maria Bartolomeo Grant · 2019 to 2026
$2.4M
NEI NIH HHS R01 EY016077NEI NIH HHS R01 EY025383NEI NIH HHS R01 EY030766
6 · The paper itself

Abstract

The fluidity and compositional heterogeneity of the mammalian plasma membrane play deterministic roles in a variety of membrane functions. Designing model bilayer systems allows for compositional control over these properties. Ceramide is a phospholipid capable of extensive headgroup-region hydrogen bonding, and we report here on the role of ceramide in planar model bilayers. We use fluorescence recovery after photobleaching (FRAP) to obtain translational diffusion constants of two chromophores in supported model bilayers composed of cholesterol, 1,2-dioleoyl-sn-phosphatidylcholine (DOPC), sphingomyelin, and ceramide. FRAP data for perylene report on the acyl chain region of the model bilayer and FRAP data for 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) sense diffusional dynamics in the bilayer headgroup region. Dynamics in the headgroup region exhibit anomalous diffusion behavior that is characteristic of spatially heterogeneous media.

Indexed as

CeramidesCholesterolDiffusionFluorescence Recovery After PhotobleachingFluorescent DyesHydrogen BondingKineticsLipid BilayersPerylenePhosphatidylcholinesPhospholipidsRhodaminesSphingomyelinsStructure-Activity Relationship1,2-oleoylphosphatidylcholineCeramidesCholesterolFluorescent DyesLipid Bilayerslissamine rhodamine BPerylenePhosphatidylcholinesPhospholipidsRhodaminesSphingomyelinsAnomalous diffusionCeramideFluorescence recovery after photobleachingHeterogeneityPhospholipidSupported lipid bilayerTranslational diffusion

Identifiers

PMID33971138
PMCPMC8222156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.