Evidence map›Paper›PMID 33971090›Full record

ArticleACS infectious diseases2021

Diaryl Ureas as an Antiprotozoal Chemotype.

Derek A Leas, Austin G Sanford, Jianbo Wu, Monica Cal, Marcel Kaiser, Sergio Wittlin, Ryan M Hemsley, Elyssa B Darner, LeeAnna M Lui, Paul H Davis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Derek A LeasCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.
Austin G SanfordDepartment of Pathology & Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska 68198-5900, United States.
Jianbo WuCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.
Monica CalUniversity of Basel, CH-4003 Basel, Switzerland.
Marcel KaiserUniversity of Basel, CH-4003 Basel, Switzerland.
Sergio WittlinUniversity of Basel, CH-4003 Basel, Switzerland.
Ryan M HemsleyDepartment of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Elyssa B DarnerDepartment of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
LeeAnna M LuiDepartment of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Paul H DavisDepartment of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.ORCID 0000-0002-0526-3841
Jonathan L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.ORCID 0000-0003-0075-2336

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
Optimization of Antischistosomal ChemotypesR01AI116723 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI VENNERSTROM, JONATHAN L · 2015 to 2024
$6.2M
NIAID NIH HHS R01 AI116723NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

We now describe the physicochemical profiling,

Indexed as

Antiprotozoal AgentsLeishmania donovaniTrypanosoma cruziAnimalsMiceTrypanosoma brucei rhodesienseUreaAntiprotozoal AgentsUreaantiprotozoalchemotypeN,N′-diarylurea

Identifiers

PMID33971090
PMCPMC8802619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.