Evidence map›Paper›PMID 33971036›Full record

Trial reportEchocardiography (Mount Kisco, N.Y.)2021

Peak atrial longitudinal strain is predictive of atrial fibrillation in patients with chronic obstructive pulmonary disease and coronary artery disease.

Rita Pavasini, Gioele Fabbri, Alessio Fiorio, Roberta Campana, Giulia Passarini, Filippo Maria Verardi, Marco Contoli, Gianluca Campo

2 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Echocardiography (Mount Kisco, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02324660 nacompletednot on this map

Prospective Evaluation of a Screening Methodology for Chronic Obstructive Pulmonary Disease in Patients Admitted to Hospital for Acute Coronary Syndromes.

TypeinterventionalSponsorUniversity Hospital of FerraraRan2014 to 2016Enrolled137ConditionsChronic Obstructive Pulmonary Disease, Acute Coronary SyndromesArmsscreening test
NCT02519608 phase2completednot on this map

Comparison Between Ticagrelor and Clopidogrel Effect on Endothelial, Platelet and Inflammation Parameters in Patients With Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease Undergoing PCI

TypeinterventionalSponsorUniversity Hospital of FerraraRan2015 to 2017Enrolled44ConditionsCoronary Artery Disease, Chronic Obstructive Pulmonary DiseaseArmsAspirin 100 mg, Ticagrelor, Clopidogrel
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rita PavasiniUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.ORCID 0000-0002-1763-9711
Gioele FabbriUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.
Alessio FiorioUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.
Roberta CampanaUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.
Giulia PassariniUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.
Filippo Maria VerardiUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.
Marco ContoliDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Gianluca CampoUO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe peak atrial longitudinal strain (PALS) has been validated in the prediction of atrial fibrillation (AF) in the general population. If this finding can be applied to patients with chronic obstructive pulmonary disease (COPD) and concomitant coronary artery disease (CAD) is unknown. METHODS AND

resultsWe analyzed two different study populations of patients with COPD and acute CAD in SCAP trial (Clinical trial.org identifier NCT02324660) and COPD and stable CAD in the NATHAN-NEVER trial (clinical trial.org identifier NCT02519608). All patients enrolled underwent spirometry and clinical specialistic evaluation to test COPD diagnosis. During the index evaluation, all patients underwent echocardiography. The primary endpoint of the study was the occurrence of AF. Overall, 175 patients have been enrolled. PALS was significantly lower in patients with COPD compared to patients without COPD (26% ± 8% vs. 30% ± 8% for PALS4CV, P = .003). After a mean follow-up of 49 ± 15 months, 26 patients experienced at least one episode of AF. At multivariable analysis, only PALS (HR: 0.92, 95% CI: 0.86-0.98, P = .014) resulted as an independent predictor of AF in COPD patients with CAD, with the best cutoff value of 25.5% (sensitivity 87% and specificity 70%).

conclusionThe present study confirmed a high incidence of AF events in COPD patients and that PALS is altered and able to independently predict AF in a specific cohort of patients with CAD and COPD. This study points out the need to integrate PALS measurement in the echocardiographic workup of all COPD patients, to early identify those at high risk of AF development.

Indexed as

Atrial FibrillationCoronary Artery DiseasePulmonary Disease, Chronic ObstructiveHumansPredictive Value of TestsRisk AssessmentRisk Factorsatrial fibrillationchronic obstructive pulmonary diseaseleft atrial longitudinal strainpeak atrial longitudinal strainstroke

Identifiers

PMID33971036
PMCPMC8252649

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.