Evidence map›Paper›PMID 33970942›Full record

ArticlePloS one2021

Structural characterisation of the Chaetomium thermophilum Chl1 helicase.

Zuzana Hodáková, Andrea Nans, Simone Kunzelmann, Shahid Mehmood, Ian Taylor, Frank Uhlmann, Peter Cherepanov, Martin R Singleton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zuzana HodákováStructural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-2599-0333
Andrea NansStructural Biology Science Technology Platform, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-3791-2447
Simone KunzelmannStructural Biology Science Technology Platform, The Francis Crick Institute, London, United Kingdom.
Shahid MehmoodProteomics Science Technology Platform, The Francis Crick Institute, London, United Kingdom.
Ian TaylorMacromolecular Structure Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-6763-3852
Frank UhlmannChromosome Segregation Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-3527-6619
Peter CherepanovChromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.
Martin R SingletonStructural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-5716-7715
The Francis Crick Institute · GB

Funding

Cancer Research UK 15671Cancer Research UK FC001155Medical Research CouncilWellcome Trust
6 · The paper itself

Abstract

Chl1 is a member of the XPD family of 5'-3' DNA helicases, which perform a variety of roles in genome maintenance and transmission. They possess a variety of unique structural features, including the presence of a highly variable, partially-ordered insertion in the helicase domain 1. Chl1 has been shown to be required for chromosome segregation in yeast due to its role in the formation of persistent chromosome cohesion during S-phase. Here we present structural and biochemical data to show that Chl1 has the same overall domain organisation as other members of the XPD family, but with some conformational alterations. We also present data suggesting the insert domain in Chl1 regulates its DNA binding.

Indexed as

ChaetomiumCrystallography, X-RayDNA HelicasesProtein ConformationSister Chromatid ExchangeS PhaseXeroderma Pigmentosum Group D ProteinDNA HelicasesXeroderma Pigmentosum Group D Protein

Identifiers

PMID33970942
PMCPMC8109800
OpenAlexW3161640894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.