ArticlePloS one2021
Cerebral oxygen saturation and cerebrovascular instability in newborn infants with congenital heart disease compared to healthy controls.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of pulmonary hypertension on long-term neurodevelopmental outcomes in preterm neonates with bronchopulmonary dysplasia: A meta-analysis.Pakistan journal of medical sciences · 2026Review
- Neonatal Cerebrovascular Stability Index and Oxygenation With 3-Month Neurodevelopmental Outcomes.JACC. Advances · 2026Article
- Near-infrared spectroscopy cerebral oximetry in pediatric congenital heart disease with cardiopulmonary bypass: a narrative review of current evidence and neuroprotection.Frontiers in pediatrics · 2026Review
- Time-dependent responses of brain injury biomarkers after severe cerebral desaturation in paediatric patients during cardiac surgery with cardiopulmonary bypass: a single-centre observational cohort study.Frontiers in cardiovascular medicine · 2026Article
- A novel nomogram for predicting early postoperative cerebral desaturation events after congenital heart surgery.Frontiers in surgery · 2026Article
- Psychiatric and Psychological Implications of Congenital Heart Disease.Journal of clinical medicine · 2025Review
- Neuromonitoring practices for neonates with congenital heart disease: a scoping review.Pediatric research · 2025Article
- Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants.Journal of clinical and translational science · 2025Article
- Association of preoperative cerebral oxygenation with concurrent neurobehavioral scores in term neonates with congenital heart disease compared to healthy controls.Frontiers in pediatrics · 2025Article
- Cerebral and Splanchnic Tissue Oxygenation Are Significantly Affected in Premature infants with Ductal-Dependent Congenital Heart Disease.Journal of pediatrics. Clinical practice · 2024Article
- Regional Cerebral Oxygen Saturation and Estimated Oxygen Extraction Ratio as Predictive Markers of Major Adverse Events in Infants with Congenital Heart Disease.Pediatric cardiology · 2024Article
- Cerebrovascular responses to a 90° tilt in healthy neonates.Pediatric research · 2024Article
- Review
- Sociodemographic Profile Associated with Congenital Heart Disease among Infants Less than 1 Year Old.Research square · 2023Article
- Factor Analysis of the Einstein Neonatal Neurobehavioral Assessment Scale in Infants with Congenital Heart Disease and Healthy Controls.Journal of child neurology · 2022Article
- Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease.Pediatric cardiology · 2022Article
- Sociodemographic profile associated with congenital heart disease among infants <1 year old.Journal of pediatric nursingArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveInfants with Congenital Heart Disease (CHD) are at risk for developmental delays, though the mechanisms of brain injury that impair development are unknown. Potential causes could include cerebral hypoxia and cerebrovascular instability. We hypothesized that we would detect significantly reduced cerebral oxygen saturation and greater cerebrovascular instability in CHD infants compared to the healthy controls.
methodsWe performed a secondary analysis on a sample of 43 term infants (28 CHD, 15 healthy controls) that assessed prospectively in temporal cross-section before or at 12 days of age. CHD infants were assessed prior to open-heart surgery. Cerebral oxygen saturation levels were estimated using Near-Infrared Spectroscopy, and cerebrovascular stability was assessed with the response of cerebral oxygen saturation after a postural change (supine to sitting).
resultsCerebral oxygen saturation was 9 points lower in CHD than control infants in both postures (β = -9.3; 95%CI = -17.68, -1.00; p = 0.028), even after controlling for differences in peripheral oxygen saturation. Cerebrovascular stability was significantly impaired in CHD compared to healthy infants (β = -2.4; 95%CI = -4.12, -.61; p = 0.008), and in CHD infants with single ventricle compared with biventricular defects (β = -1.5; 95%CI = -2.95, -0.05; p = 0.04).
conclusionCHD infants had cerebral hypoxia and decreased cerebral oxygen saturation values following a postural change, suggesting cerebrovascular instability. Future longitudinal studies should assess the associations of cerebral hypoxia and cerebrovascular instability with long-term neurodevelopmental outcomes in CHD infants.
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