ArticlePloS one2021
Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model.Annals of biomedical engineering · 2025Article
- Proof of concept validation of bioresorbable optical fibers for diffuse correlation spectroscopy.Biomedical optics express · 2024Article
- Porcine Models of Spinal Cord Injury.Biomedicines · 2023Review
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Lossless Compressed Sensing of Photon Counts for Fast Diffuse Correlation Spectroscopy.IEEE access : practical innovations, open solutions · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Spinal cord ischemia leads to iatrogenic injury in multiple surgical fields, and the ability to immediately identify onset and anatomic origin of ischemia is critical to its management. Current clinical monitoring, however, does not directly measure spinal cord blood flow, resulting in poor sensitivity/specificity, delayed alerts, and delayed intervention. We have developed an epidural device employing diffuse correlation spectroscopy (DCS) to monitor spinal cord ischemia continuously at multiple positions. We investigate the ability of this device to localize spinal cord ischemia in a porcine model and validate DCS versus Laser Doppler Flowmetry (LDF). Specifically, we demonstrate continuous (>0.1Hz) spatially resolved (3 locations) monitoring of spinal cord blood flow in a purely ischemic model with an epidural DCS probe. Changes in blood flow measured by DCS and LDF were highly correlated (r = 0.83). Spinal cord blood flow measured by DCS caudal to aortic occlusion decreased 62%. This monitor demonstrated a sensitivity of 0.87 and specificity of 0.91 for detection of a 25% decrease in flow. This technology may enable early identification and critically important localization of spinal cord ischemia.
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Registered trials
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