SynthesisPLoS medicine2021
Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis.
Synthesis in PLoS medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 374 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness Of A Community-based Video-facilitated Parenting Intervention For Child Development Integrated Into Routine Maternal And Child Care Services In India: Study Protocol
Building Opportunities for Nurturing Care to Enhance Development in Eastern and Southern Africa
Who cites it
374 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Strengthening Early Childhood Development Programs and Interventions in Low- and Middle-Income Countries: Systematic Review of Interventions.Maternal & child nutrition · 2026Pooled it
- Home-Based Learning Opportunities, Responsive Caregiving and the Development of Preschool-Aged Children in Low- and Middle-Income Countries of the East Asia and Pacific Region: A Systematic Review.Child: care, health and development · 2026Pooled it
- Universal interventions to improve young children's mental well-being: A systematic review and meta-analysis.Psychological bulletin · 2026Pooled it
- Annual Research Review: The role of caregiver sensitivity in children's developmental outcomes - an umbrella review.Journal of child psychology and psychiatry, and allied disciplines · 2026Pooled it
- A Systematic Review and Evidence Gap Map Evaluation of Rhythmic and/or Complex Movement Interventions and Child Cognitive Outcomes.Clinical child and family psychology review · 2025Pooled it
- Positive and negative parenting practices and offspring disruptive behavior: A meta-analytic review of quasi-experimental evidence.Psychological bulletin · 2025Pooled it
- Effects of integrated programs for substance-involved mothers on infant and child development outcomes: A systematic review and meta-analysis.Infant mental health journal · 2025Pooled it
- Psychosocial adversity and executive functions in children and adolescents: a systematic review of mediating and moderating influences of parenting behaviors.BMC psychiatry · 2025Pooled it
- Where Is the Parent's Voice? A Meta-Synthesis of Parental Experiences of Video Feedback Parenting Interventions.Clinical child and family psychology review · 2025Pooled it
- Post-Asphyxial Aftercare and Management of Neonates in Low- and Middle-Income Countries: A Systematic Evidence Synthesis.Neonatology · 2025Pooled it
- Effectiveness of the Moments that Matter parenting programme on caregiving practices, family violence, mental health and early child development in Kenya: a cluster-randomised controlled trial.BMJ global health · 2026Trial
- Little All Children in Focus (Little ACF) - evaluation of a parenting support programme for parents of children aged 1-2 years in Sweden: a randomised controlled trial.BMC public health · 2026Trial
- Digital support systems to improve child development in Peru: A cluster-randomized controlled open-label trial.Science advances · 2026Trial
- Effects of Engaging Fathers and Bundling Nutrition and Parenting Interventions on Child Nutrition Outcomes and Related Parent Behaviors in Rural Tanzania: Results From EFFECTS, a Five-Arm Cluster-Randomized Controlled Trial.Maternal & child nutrition · 2026Trial
- Blended Delivery of a Primary Care Parenting Program for Child Development: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Family Engagement in an Early Childhood Preventive Parenting Program: Innovative Methods for Examining Sociodemographic, Psychosocial, and Contextual Predictors.Prevention science : the official journal of the Society for Prevention Research · 2026Trial
- Trial
- An online randomised controlled trial to evaluate the effectiveness of an online intervention for parents/guardians of children aged 4-7 years old who are concerned about their children's emotional and behavioural development: EMERGENT study.Frontiers in psychology · 2026Trial
- Trial
- Caregivers' early stimulation behaviors on early child development outcomes in Northern Ghana.PloS one · 2026Trial
314 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParents are the primary caregivers of young children. Responsive parent-child relationships and parental support for learning during the earliest years of life are crucial for promoting early child development (ECD). We conducted a global systematic review and meta-analysis to evaluate the effectiveness of parenting interventions on ECD and parenting outcomes. METHODS AND
findingsWe searched MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and Global Health Library for peer-reviewed, published articles from database inception until November 15, 2020. We included randomized controlled trials (RCTs) of parenting interventions delivered during the first 3 years of life that evaluated at least 1 ECD outcome. At least 2 reviewers independently screened, extracted data, and assessed study quality from eligible studies. ECD outcomes included cognitive, language, motor, and socioemotional development, behavior problems, and attachment. Parenting outcomes included parenting knowledge, parenting practices, parent-child interactions, and parental depressive symptoms. We calculated intervention effect sizes as the standardized mean difference (SMD) and estimated pooled effect sizes for each outcome separately using robust variance estimation meta-analytic approaches. We used random-effects meta-regression models to assess potential effect modification by country-income level, child age, intervention content, duration, delivery, setting, and study quality. This review was registered with PROSPERO (CRD42018092458 and CRD42018092461). Of the 11,920 articles identified, we included 111 articles representing 102 unique RCTs. Pooled effect sizes indicated positive benefits of parenting interventions on child cognitive development (SMD = 0.32, 95% CI [confidence interval]: 0.23, 0.40, P < 0.001), language development (SMD = 0.28, 95% CI: 0.18 to 0.37, P < 0.001), motor development (SMD = 0.24, 95% CI: 0.15 to 0.32, P < 0.001), socioemotional development (SMD = 0.19, 95% CI: 0.10 to 0.28, P < 0.001), and attachment (SMD = 0.29, 95% CI: 0.18 to 0.40, P < 0.001) and reductions in behavior problems (SMD = -0.13, 95% CI: -0.18 to -0.08, P < 0.001). Positive benefits were also found on parenting knowledge (SMD = 0.56, 95% CI: 0.33 to 0.79, P < 0.001), parenting practices (SMD = 0.33, 95% CI: 0.22 to 0.44, P < 0.001), and parent-child interactions (SMD = 0.39, 95% CI: 0.24 to 0.53, P < 0.001). However, there was no significant reduction in parental depressive symptoms (SMD = -0.07, 95% CI: -0.16 to 0.02, P = 0.08). Subgroup analyses revealed significantly greater effects on child cognitive, language, and motor development, and parenting practices in low- and middle-income countries compared to high-income countries; and significantly greater effects on child cognitive development, parenting knowledge, parenting practices, and parent-child interactions for programs that focused on responsive caregiving compared to those that did not. On the other hand, there was no clear evidence of effect modification by child age, intervention duration, delivery, setting, or study risk of bias. Study limitations include considerable unexplained heterogeneity, inadequate reporting of intervention content and implementation, and varying quality of evidence in terms of the conduct of trials and robustness of outcome measures used across studies.
conclusionsParenting interventions for children during the first 3 years of life are effective for improving ECD outcomes and enhancing parenting outcomes across low-, middle-, and high-income countries. Increasing implementation of effective and high-quality parenting interventions is needed globally and at scale in order to support parents and enable young children to achieve their full developmental potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.