ArticlePLoS computational biology2021
Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07369115 (Intra-Cellular Therapies, Inc. / "A Randomized, Double-blind, Placebo-controlled, Single Site Study to Evaluate the Efficacy of Lumateperone for the Treatment of Major Depressive Disorder), which is not on this map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-Cellular Therapies, Inc. / "A Randomized, Double-blind, Placebo-controlled, Single Site Study to Evaluate the Efficacy of Lumateperone for the Treatment of Major Depressive Disorder (MDD) and Early Life Trauma in Adult Patients Aged 21 to 70 Years
Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Selective enhancement of cost sensitivity by methylphenidate in adult ADHD: a randomized placebo-controlled trial.Psychological medicine · 2026Trial
- HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neurocognitive Modeling.bioRxiv : the preprint server for biology · 2026Article
- Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.bioRxiv : the preprint server for biology · 2026Article
- Article
- Eliciting social approach-avoidance conflict within a novel experimental paradigm: psychometric and computational evidence with a successful pre-registered replication.Cognition & emotion · 2026Article
- A novel approach-avoidance task to study decision making under outcome uncertainty.Psychonomic bulletin & review · 2026Article
- Predicting substance use behaviors with machine learning using small sets of judgment and contextual variables.Npj mental health research · 2026Article
- Neural Compensation in the Medial Prefrontal Cortex Preserves Self-Prioritization in Aging: A Computational Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Treatment-resistant recurrent unipolar and bipolar depression: associative learning abnormalities.Brain : a journal of neurology · 2025Article
- The neurocognitive mechanism underlying math avoidance among math anxious people.NPJ science of learning · 2025Article
- Differences in Reward and Punishment Sensitivity among Adolescents with Depression Varying in Manic Symptoms.Research on child and adolescent psychopathology · 2025Article
- Agent-Based Behavioral Modeling of Human Associative Learning in a Complex Approach-Avoidance Conflict Task.Computational brain & behavior · 2025Article
- Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Developing algorithmic psychiatry via multi-level spanning computational models.Cell reports. Medicine · 2025Review
- Adult age differences in the integration of values for self and other.Scientific reports · 2025Article
- Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans.PLoS biology · 2025Article
- Reward-Related Brain Activity Mediates the Relationship Between Decision-Making Deficits and Pediatric Depression Symptom Severity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Basal ganglia components have distinct computational roles in decision-making dynamics under conflict and uncertainty.PLoS biology · 2025Article
- Increasing the Construct Validity of Computational Phenotypes of Mental Illness Through Active Inference and Brain Imaging.Brain sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Adaptive behavior requires balancing approach and avoidance based on the rewarding and aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a novel application of the drift diffusion model (DDM) suited to quantify how offers of reward and aversiveness, and neural correlates thereof, are dynamically integrated to form decisions, and how such processes are altered in MDD. Hierarchical parameter estimation from the DDM demonstrated that the MDD group differed in three distinct reward-related parameters driving approach-based decision making. First, MDD was associated with reduced reward sensitivity, measured as the impact of offered reward on evidence accumulation. Notably, this effect was replicated in a follow-up study. Second, the MDD group showed lower starting point bias towards approaching offers. Third, this starting point was influenced in opposite directions by Pavlovian effects and by nucleus accumbens activity across the groups: greater accumbens activity was related to approach bias in controls but avoid bias in MDD. Cross-validation revealed that the combination of these computational biomarkers were diagnostic of patient status, with accumbens influences being particularly diagnostic. Finally, within the MDD group, reward sensitivity and nucleus accumbens parameters were differentially related to symptoms of perceived stress and depression. Collectively, these findings establish the promise of computational psychiatry approaches to dissecting approach-avoidance decision dynamics relevant for affective disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.