Evidence map›Paper›PMID 33970896›Full record

Observational studyActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2021

COVID-19 in the tonsillectomised population.

Vincenzo Capriotti, Francesco Mattioli, Francesco Guida, Alberto Vito Marcuzzo, Alfredo Lo Manto, Andrea Martone, Giulia Molinari, Cristoforo Fabbris, Anna Menegaldo, Leonardo Calvanese and 24 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Discrepancies of SARS-CoV-2 testing results among patients with total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 8 institutions in 2 countries.

Vincenzo Capriotti *Otorhinolaryngology-Head and Neck Surgery Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Francesco Mattioli *Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy.
Francesco GuidaOtorhinolaryngology-Head and Neck Surgery Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Alberto Vito MarcuzzoOtorhinolaryngology-Head and Neck Surgery Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Alfredo Lo MantoOtorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy.
Andrea MartoneOtorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy.
Giulia MolinariOtorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy.
Cristoforo FabbrisENT Clinic and Regional Center for Head and Neck Cancer, University of Padova Faculty of Medicine and Surgery, Department of Neurosciences, Treviso Regional Hospital, Treviso, Italy.
Anna MenegaldoENT Clinic and Regional Center for Head and Neck Cancer, University of Padova Faculty of Medicine and Surgery, Department of Neurosciences, Treviso Regional Hospital, Treviso, Italy.
Leonardo CalvaneseENT Clinic and Regional Center for Head and Neck Cancer, University of Padova Faculty of Medicine and Surgery, Department of Neurosciences, Treviso Regional Hospital, Treviso, Italy.
Gino LatiniInstitute of Otorhinolaryngology, Department of Head and Neck Surgery, Santa Croce Hospital AORMN, Fano (PU), Italy.
Cristina CingolaniInstitute of Otorhinolaryngology, Department of Head and Neck Surgery, Santa Croce Hospital AORMN, Fano (PU), Italy.
Paolo GradoniInstitute of Otorhinolaryngology, Department of Head and Neck Surgery, Santa Croce Hospital AORMN, Fano (PU), Italy.
Francesca Boscolo NataOtorhinolaryngology Unit, Monselice Hospital, Ospedali Riuniti Padova Sud "Madre Teresa di Calcutta", Monselice (PD), Italy.
Clelia De SistiHygiene and Public Health Unit, Department of Prevention, Hospital of Chioggia, AULSS 3 Serenissima, Chioggia (VE), Italy.
Vittorio SelleHygiene and Public Health Unit, Department of Prevention, Hospital of Chioggia, AULSS 3 Serenissima, Chioggia (VE), Italy.
Giordano LeoneDepartment of Otorhinolaryngology, San Raffaele Hospital, Milano, Italy.
Pietro IndelicatoDepartment of Otorhinolaryngology, San Raffaele Hospital, Milano, Italy.
Francesco PilolliDepartment of Otorhinolaryngology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Niccolò MevioDepartment of Otorhinolaryngology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Luca RoncoroniDepartment of Otorhinolaryngology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Simona PapiDepartment of Surgery and Clinical Specialties, University of Modena and Reggio Emilia, Modena, Italy.
Marianna MeschiariDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico of Modena, University of Modena and Reggio Emilia Faculty of Medicine and Surgery, Modena, Italy.
Riccardo TominzDepartment of Prevention, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Luca D'AscanioInstitute of Otorhinolaryngology, Department of Head and Neck Surgery, Santa Croce Hospital AORMN, Fano (PU), Italy.
Alberto DragonettiDepartment of Otorhinolaryngology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Lucio TorelliDepartment of Medical, Surgical and Health Sciences, University of Trieste, Italy.
Loris TrentiDepartment of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, Barcelona, Spain.
Giacomo SpinatoENT Clinic and Regional Center for Head and Neck Cancer, University of Padova Faculty of Medicine and Surgery, Department of Neurosciences, Treviso Regional Hospital, Treviso, Italy.
Paolo Boscolo-RizzoENT Clinic and Regional Center for Head and Neck Cancer, University of Padova Faculty of Medicine and Surgery, Department of Neurosciences, Treviso Regional Hospital, Treviso, Italy.
Mario BussiHygiene and Public Health Unit, Department of Prevention, Hospital of Chioggia, AULSS 3 Serenissima, Chioggia (VE), Italy.
Andrea CossarizzaDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Livio PresuttiOtorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy.
Giancarlo TirelliOtorhinolaryngology-Head and Neck Surgery Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
University of Modena and Reggio Emilia · ITAzienda Sanitaria Universitaria Integrata di Trieste · ITCa' Foncello Hospital · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITVita-Salute San Raffaele University · ITBellvitge University Hospital · ESPoliclinico di Modena · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInteractions between SARS-CoV-2 and pharyngeal associated lymphoid tissue are thought to influence the manifestations of COVID-19. We aimed to determine whether a previous history of tonsillectomy, as a surrogate indicator of a dysfunctional pharyngeal associated lymphoid tissue, could predict the presentation and course of COVID-19.

methodsMulticentric cross-sectional observational study involving seven hospitals in Northern and Central Italy. Data on the clinical course and signs and symptoms of the infection were collected from 779 adults who tested positive for SARS-CoV-2, and analysed in relation to previous tonsillectomy, together with demographic and anamnestic data.

resultsPatients with previous tonsillectomy showed a greater risk of fever, temperature higher than 39°C, chills and malaise. No significant differences in hospital admissions were found.

conclusionsA previous history of tonsillectomy, as a surrogate indicator of immunological dysfunction of the pharyngeal associated lymphoid tissue, could predict a more intense systemic manifestation of COVID-19. These results could provide a simple clinical marker to discriminate suspected carriers and to delineate more precise prognostic models.

Indexed as

COVID-19Palatine TonsilAdultAgedCross-Sectional StudiesFemaleHumansItalyMaleMiddle AgedPandemicsSARS-CoV-2TonsillectomycoronavirusCOVID-19SARS-CoV-2tonsillectomytonsils

Identifiers

PMID33970896
PMCPMC8283408
OpenAlexW3163484610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.