Evidence map›Paper›PMID 33970608›Full record

ArticleACS synthetic biology2021

Encounters between Cas9/dCas9 and G-Quadruplexes: Implications for Transcription Regulation and Cas9-Mediated DNA Cleavage.

Mohammed Enamul Hoque, Golam Mustafa, Soumitra Basu, Hamza Balci

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cap-Independent Translation Regulation of VEGF Using CRISPR-dCas13d.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohammed Enamul HoqueDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0003-2439-2355
Golam MustafaDepartment of Physics, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0001-8683-1638
Soumitra BasuDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0001-6904-8019
Hamza BalciDepartment of Physics, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0002-0273-4871
Kent State University · US

Funding

Influence of small molecules on G-quadruplex stability, folding kinetics, and interactions with proteinsR15GM123443 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2018 to 2018
$438k
NIGMS NIH HHS R15 GM123443
6 · The paper itself

Abstract

Using the nuclease-dead Cas9 (dCas9), we targeted

Indexed as

CRISPR-Cas SystemsDNA CleavageG-QuadruplexesCell Line, TumorClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated Protein 9Gene Expression RegulationHumansMutationNeuroblastomaPromoter Regions, GeneticTranscription, GeneticTransfectionTyrosine 3-MonooxygenaseCRISPR-Associated Protein 9Tyrosine 3-MonooxygenaseCas9CRISPRdCas9DNA cleavageG-quadruplextranscription regulation

Identifiers

PMID33970608
PMCPMC9285135
OpenAlexW3163596473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.