Evidence map›Paper›PMID 33970552›Full record

ReviewAdvanced healthcare materials2021

PEDOT:PSS-Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals.

Yuanying Liang, Andreas Offenhäusser, Sven Ingebrandt, Dirk Mayer

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Laser-Defined States and Hydration-Driven Relaxation in PEDOT:PSS.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Article
  14. PEDOT:PSS-A Key Material for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuanying LiangInstitute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, Guangdong, 510640, China.
Andreas OffenhäusserInstitute of Biological Information Processing, Bioelectronics IBI-3, Forschungszentrum Jülich, Jülich, 52425, Germany.ORCID 0000-0001-6143-2702
Sven IngebrandtFaculty of Electrical Engineering and Information Technology, Institute of Materials in Electrical Engineering 1, RWTH Aachen University, Aachen, 52074, Germany.ORCID 0000-0002-0405-2727
Dirk MayerInstitute of Biological Information Processing, Bioelectronics IBI-3, Forschungszentrum Jülich, Jülich, 52425, Germany.ORCID 0000-0003-1296-8265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To understand the physiology and pathology of electrogenic cells and the corresponding tissue in their full complexity, the quantitative investigation of the transmission of ions as well as the release of chemical signals is important. Organic (semi-) conducting materials and in particular organic electrochemical transistor are gaining in importance for the investigation of electrophysiological and recently biochemical signals due to their synthetic nature and thus chemical diversity and modifiability, their biocompatible and compliant properties, as well as their mixed electronic and ionic conductivity featuring ion-to-electron conversion. Here, the aim is to summarize recent progress on the development of bioelectronic devices utilizing polymer polyethylenedioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) to interface electronics and biological matter including microelectrode arrays, neural cuff electrodes, organic electrochemical transistors, PEDOT:PSS-based biosensors, and organic electronic ion pumps. Finally, progress in the material development is summarized for the improvement of polymer conductivity, stretchability, higher transistor transconductance, or to extend their field of application such as cation sensing or metabolite recognition. This survey of recent trends in PEDOT:PSS electrophysiological sensors highlights the potential of this multifunctional material to revolve current technology and to enable long-lasting, multichannel polymer probes for simultaneous recordings of electrophysiological and biochemical signals from electrogenic cells.

Indexed as

Bridged Bicyclo Compounds, HeterocyclicPolymersElectric ConductivityMicroelectrodesBridged Bicyclo Compounds, Heterocyclicpoly(3,4-ethylene dioxythiophene)Polymersbioelectronic devicesbiosensorselectrophysiological signalsions and neurotransmitterspolymer polyethylenedioxythiophene: poly(styrene sulfonate)

Identifiers

PMID33970552
PMCPMC11468774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.