Evidence map›Paper›PMID 33970510›Full record

ArticleJournal of magnetic resonance imaging : JMRI2021

Multitask Learning Based Three-Dimensional Striatal Segmentation of MRI: fMRI and PET Objective Assessments.

Mario Serrano-Sosa, Jared X Van Snellenberg, Jiayan Meng, Jacob R Luceno, Karl Spuhler, Jodi J Weinstein, Anissa Abi-Dargham, Mark Slifstein, Chuan Huang

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mario Serrano-SosaDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Jared X Van SnellenbergDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Jiayan MengDepartment of Psychiatry and Behavioral Health, Stony Brook Medicine, Stony Brook, New York, USA.
Jacob R LucenoDepartment of Psychiatry and Behavioral Health, Stony Brook Medicine, Stony Brook, New York, USA.
Karl SpuhlerDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Jodi J WeinsteinDepartment of Psychiatry and Behavioral Health, Stony Brook Medicine, Stony Brook, New York, USA.
Anissa Abi-DarghamDepartment of Psychiatry and Behavioral Health, Stony Brook Medicine, Stony Brook, New York, USA.
Mark SlifsteinDepartment of Psychiatry and Behavioral Health, Stony Brook Medicine, Stony Brook, New York, USA.
Chuan HuangDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-6052-0663
Stony Brook Medicine · USStony Brook University · USWinthrop-University Hospital · US

Funding

Dopamine Dysfunction in SchizophreniaP50MH086404 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI ABI-DARGHAM, ANISSA · 2010 to 2014
$9.4M
Towards an Integrated Understanding of Neurotransmitter Dysfunction in Schizophrenia: a Multimodal MRI StudyK23MH115291 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI WEINSTEIN, JODI JAY · 2018 to 2024
$1.2M
Translational Neuroscience of Functional Connectivity in SchizophreniaK01MH107763 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI VAN SNELLENBERG, JARED XAVIER · 2015 to 2019
$961k
Probing dopamine D2 receptor trafficking in schizophreniaR21MH099509 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI ABI-DARGHAM, ANISSA · 2013 to 2014
$455k
NIMH NIH HHS K01 MH107763NIMH NIH HHS K23 MH115291NIMH NIH HHS P50 MH086404NIMH NIH HHS R21 MH099509
6 · The paper itself

Abstract

backgroundRecent studies have established a clear topographical and functional organization of projections to and from complex subdivisions of the striatum. Manual segmentation of these functional subdivisions is labor-intensive and time-consuming, and automated methods are not as reliable as manual segmentation. PURPOSE: To utilize multitask learning (MTL) as a method to segment subregions of the striatum consisting of pre-commissural putamen (prePU), pre-commissural caudate (preCA), post-commissural putamen (postPU), post-commissural caudate (postCA), and ventral striatum (VST). STUDY TYPE: Retrospective. POPULATION: Eighty-seven total data sets from patients with schizophrenia and matched controls. FIELD STRENGTH/SEQUENCE: 1.5 T and 3.0 T, T ASSESSMENT: MTL-generated segmentations were compared to the Imperial College London Clinical Imaging Center (CIC) atlas. Dice similarity coefficient (DSC) was used to compare the automated methods to manual segmentations. Positron emission tomography (PET) imaging: 60 minutes of emission data were acquired using [ STATISTICAL TESTS: Pearson correlation and paired t-test.

resultsMTL-generated segmentations showed excellent spatial agreement with manual (DSC ≥0.72 across all striatal subregions). BP DATA

conclusionAcross both PET and fMRI task-based assessments, results from MTL-generated segmentations more closely corresponded to results from manually drawn ROIs than CIC-generated segmentations did. Therefore, the proposed MTL approach is a fast and reliable method for three-dimensional striatal subregion segmentation with results comparable to manually segmented ROIs. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 1.

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyBrainCorpus StriatumHumansRetrospective StudiesMRImultitask learningPETstriatal segmentation

Identifiers

PMID33970510
PMCPMC9204799
OpenAlexW3162901578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.