ArticleInfection2021
National Early Warning Score 2 (NEWS2) better predicts critical Coronavirus Disease 2019 (COVID-19) illness than COVID-GRAM, a multi-centre study.
Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Applications of the Early Warning Score as an outcome measure: a systematic review of methodologies.BMJ health & care informatics · 2026Pooled it
- Prognostic models in COVID-19 infection that predict severity: a systematic review.European journal of epidemiology · 2023Pooled it
- The Prognostic Accuracy of National Early Warning Score 2 on Predicting Clinical Deterioration for Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Ion channel inhibition with amiodarone or verapamil in symptomatic hospitalized nonintensive-care COVID-19 patients: The ReCOVery-SIRIO randomized trial.Cardiology journal · 2022Trial
- Mortality prediction by quick Sequential Organ Failure Assessment, National Early Warning Score 2, Shock Index, and Modified Shock Index in suspected sepsis: A retrospective study.The Journal of international medical research · 2026Observational
- Performance of risk prediction scores for severe pneumonia in patients with community-acquired pneumonia after organ transplantation.ERJ open research · 2025Article
- Evaluating the predictive performance of PIRO score against six clinical prediction scores for COVID-19 outcomes in the emergency department.Scientific reports · 2025Article
- Performance of Risk Scores in SARS-CoV-2 Infection: A Retrospective Study.International journal of environmental research and public health · 2025Observational
- Evaluation of physiological severity scores for predicting COVID-19 disease progression: a retrospective study.BMC infectious diseases · 2025Article
- Time‑dependent ROC curve analysis to determine the predictive capacity of seven clinical scales for mortality in patients with COVID‑19: Study of a hospital cohort with very high mortality.Biomedical reports · 2024Article
- Presepsin as a prognostic biomarker in COVID-19 patients: combining clinical scoring systems and laboratory inflammatory markers for outcome prediction.Virology journal · 2024Article
- The National Early Warning Score 2 with Age and Body Mass Index (NEWS2 Plus) to Determine Patients with Severe COVID-19 Pneumonia.Journal of clinical medicine · 2024Article
- Outcomes of adults hospitalized with COVID-19 at the University Teaching Hospital of Butare in Rwanda and validation of the Universal Vital Assessment (UVA) mortality risk score.PLOS global public health · 2024Article
- The 123 COVID SCORE: A simple and reliable diagnostic tool to predict in-hospital death in COVID-19 patients on hospital admission.PloS one · 2024Article
- SUPER Score Contributes to Warning and Management in Early-Stage COVID-19.Infectious medicine · 2023Article
- Article
- Hemodynamic, Oxygenation and Lymphocyte Parameters Predict COVID-19 Mortality.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Prehospital physiological parameters related illness severity scores can accurately discriminate the severe/critical state in adult patients with COVID-19.Annals of medicine · 2023Article
- Modeling mortality risk in patients with severe COVID-19 from Mexico.Frontiers in medicine · 2023Article
- Multicenter validation of Early Warning Scores for detection of clinical deterioration in COVID-19 hospitalized patients.Medicina intensiva · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClinical scores to rapidly assess the severity illness of Coronavirus Disease 2019 (COVID-19) could be considered of help for clinicians. Recently, a specific score (named COVID-GRAM) for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, based on a nationwide Chinese cohort, has been proposed. We routinely applied the National Early Warning Score 2 (NEWS2) to predict critical COVID-19. Aim of this study is to compare NEWS2 and COVID-GRAM score.
methodsWe retrospectively analysed data of 121 COVID-19 patients admitted in two Clinics of Infectious Diseases in the Umbria region, Italy. The primary outcome was critical COVID-19 illness defined as admission to the intensive care unit, invasive ventilation, or death. Accuracy of the scores was evaluated with the area under the receiver-operating characteristic curve (AUROC). Differences between scores were confirmed used Hanley-McNeil test.
resultsThe NEWS2 AUROC curve measured 0.87 (standard error, SE 0.03; 95% CI 0.80-0.93; p < 0.0001). The COVID-GRAM score AUROC curve measured 0.77 (SE 0.04; 95% CI 0.68-0.85; p < 0.0001). Hanley-McNeil test showed that NEWS2 better predicted severe COVID-19 (Z = 2.03).
conclusionsThe NEWS2 showed superior accuracy to COVID-GRAM score for prediction of critical COVID-19 illness.
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