Evidence map›Paper›PMID 33970397›Full record

ArticleMolecular biology reports2021

Metals toxicity and its correlation with the gene expression in Alzheimer's disease.

Jyoti Yadav, Anoop Kumar Verma, Md Kaleem Ahmad, Ravindra K Garg, Shiuli, Abbas Ali Mahdi, Shrikant Srivastava

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Are high copper levels related to Alzheimer's and Parkinson's diseases? A systematic review and meta-analysis of articles published between 2011 and 2022.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Pooled it
  3. Review
  4. Article
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  6. Article
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  12. Metals in Alzheimer's Disease.Biomedicines · 2023
    Review
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jyoti YadavForensic Medicine & Toxicology Department, King George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Anoop Kumar VermaForensic Medicine & Toxicology Department, King George's Medical University, Lucknow, Uttar Pradesh, 226003, India. vermakgmc@gmail.com.ORCID http://orcid.org/0000-0003-2446-585X
Md Kaleem AhmadBiochemistry Department, KGMU, Lucknow, India.
Ravindra K GargNeurology Department, KGMU, Lucknow, India.
ShiuliForensic Medicine & Toxicology Department, King George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Abbas Ali MahdiBiochemistry Department, KGMU, Lucknow, India.
Shrikant SrivastavaGeriatric Mental Health Department, KGMU, Lucknow, India.
King George's Medical University · IN

Funding

King George's Medical University 95th ECM II B IMR-F/P2University Grants Commission 3359/(OBC) (NET-DEC.2015)
6 · The paper itself

Abstract

Alzheimer's disease is a common neurodegenerative disease in the elderly population and a leading cause of dementia. Genetics and environmental risk factors were considered to play a major role in the onset of the disease. This study aimed to examine the correlation between different metals levels and the gene expression in Alzheimer's patients with age-matched control subjects. Non- essential metals were measured in the whole blood due to its higher concentration in red blood corpuscles (RBCs) and essential biometals in the serum samples of Alzheimer's disease (AD) by using Inductively coupled plasma optical emission spectroscopy (ICP-OES) that allows the analysis and detection of the different elements at low levels. Gene expression level was performed by quantitative real-time PCR (qRT-PCR). In this study, the levels of Lead and Arsenic metals were not detected in the AD patient samples. Cadmium, Mercury, and Aluminum were found higher in cases as compared to controls with 0.009240 ± 0.0007707 (P =  < 0.0001), 0.02332 ± 0.001041 (P =  < 0.0001), and 0.09222 ± 0.02804 (P = 0.0087) respectively. Essential biometal like copper was higher 0.1274 ± 0.02453 (P = 0.0254) in cases, while iron 0.1117 ± 0.009599 (P = 0.0304) and zinc 0.03800 ± 0.003462 mg/L were found significantly lower as compared to controls. All targeted genes such as APP, PSEN1, PSEN2, and APOE4 were found up-regulated in AD patients. We concluded that there was no significant correlation between metals dyshomeostasis and gene expressions in this study.

Indexed as

Gene ExpressionAgedAluminumAlzheimer DiseaseApolipoproteinsApolipoproteins ECadmiumCopperFemaleHumansIronMaleMetalsNeurodegenerative DiseasesPresenilin-1Presenilin-2AluminumApolipoproteinsApolipoproteins ECadmiumCopperIronMetalsPresenilin-1Presenilin-2PSEN1 protein, humanZincAlzheimer's diseaseAmyloid-beta plaqueApolipoproteinGene expressionNeurodegenerative diseaseNon- essential metals

Identifiers

PMID33970397
OpenAlexW3162920553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.