ArticleEuropean journal of pediatrics2021
Muscle mass change during chemotherapy in children with high-risk neuroblastoma: a retrospective case series of 24 patients.
Article in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- The Reliability of Measuring Muscle Cross-Sectional Area in Children Undergoing Treatment for Musculoskeletal Sarcoma.Journal of cachexia, sarcopenia and muscle · 2026Article
- Sarcopenia in children with acute leukemia worsened after induction therapy.Endocrine journal · 2025Article
- Article
- Body composition changes in pediatric patients with lymphoma after chemotherapy: a retrospective study.European journal of pediatrics · 2025Observational
- Bioelectrical Impedance Analysis of Body Composition in Male Childhood Brain Tumor Survivors.Diseases (Basel, Switzerland) · 2024Article
- Clinical significance of sarcopenia in children with neuroblastic tumors.Pediatric surgery international · 2024Observational
- Nutritional status, body composition and diet quality in children with cancer.Frontiers in oncology · 2024Review
- Review
- Total Psoas Muscle Area as a Marker for Sarcopenia Is Related to Outcome in Children With Neuroblastoma.Frontiers in surgery · 2021Article
- Anthropometrics, body composition, sarcopenia, and frailty in intestinal transplantation: A literature review and commentary.Intestinal Failure (New York, N.Y.)Review
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9 authors at 2 institutions in 1 country.
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Abstract
The clinical characteristics, cause, and risk factors of sarcopenia are unclear in children. The aim of this study was to describe the course of and identify the factors related to muscle mass change during chemotherapy in children with neuroblastoma. A total of 24 consecutive patients aged below 18 years with newly diagnosed high-risk neuroblastoma between 2010 and 2018 in our hospital were enrolled in a case-series study. The psoas muscle index (PMI) was calculated as a parameter of muscle mass based on computer tomography (CT) images of the psoas muscle. PMIs were evaluated at 4 time points (TPs): TP1, at the diagnosis of neuroblastoma; TP2, after the first cycle of chemotherapy; TP3, after the third cycle of chemotherapy; and TP4, at the end of the induction chemotherapy. PMI recovery was defined as an increase in PMI between TP2 and TP4. The mean PMI decreased by 15% between TP1 and TP2 (TP1 7.09 ± 0.99 vs. TP2 6.01 ± 0.98, P < 0.001) and by 10% between TP1 and TP4 (TP1 7.09 vs. TP4 6.35, P = 0.004). PMI recovery between TP1 and TP2 was observed in 7 (29%) patients. The median age of patients with PMI recovery was significantly lower (2 vs. 4 years, P = 0.028), and the proportion of boys was significantly higher in patients with PMI recovery (100% vs. 41%, P = 0.017).Conclusion: This study demonstrated that prominent PMI reduction occurs during the early time of chemotherapy, and a younger age and male sex may be predictive factors for PMI recovery. What is Known: • Sarcopenia is a common disorder in elderly people. • Several causes and risk factors have been reported in adults. • Children with previous hematological malignancies have decreased physical activity. What is New: • Prominent muscle mass loss was observed early in children with high-risk neuroblastoma during chemotherapy. • Age and sex were found to be potentially associated with muscle mass recovery.
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