ArticleThe Journal of infectious diseases2021
Psychosocial Stress Alters the Immune Response and Results in Higher Viral Load During Acute Simian Immunodeficiency Virus Infection in a Pigtailed Macaque Model of Human Immunodeficiency Virus.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Evaluating Behavioral Management Practices for Laboratory Nonhuman Primates: An International Survey.Animals : an open access journal from MDPI · 2026Article
- Social Housing of Postoperative Animals to Support Animal Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- A Metric-Based, Meta-Analytic Appraisal of Environmental Enrichment Efficacy in Captive Primates.Animals : an open access journal from MDPI · 2025Review
- Refinements in Clinical and Behavioral Management for Macaques on Infectious Disease Protocols.Veterinary sciences · 2024Review
- Early-life behavioral features are associated with chronic emesis in rhesus macaques (Macaca mulatta).American journal of primatology · 2023Article
- Effect of Caging onMicroorganisms · 2022Article
- Improving transparency-A call to include social housing information in biomedical research articles involving nonhuman primates.American journal of primatology · 2022Article
- Review
- The Symbiotic Relationship Between Scientific Quality and Animal Research Ethics.ILAR journal · 2021Article
- Temperament Predicts the Quality of Social Interactions in Captive Female Rhesus Macaques (Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough social distancing is a key public health response during viral pandemics, psychosocial stressors, such as social isolation, have been implicated in adverse health outcomes in general [1] and in the context of infectious disease, such as human immunodeficiency virus (HIV) [2, 3]. A comprehensive understanding of the direct pathophysiologic effects of psychosocial stress on viral pathogenesis is needed to provide strategic and comprehensive care to patients with viral infection.
methodsTo determine the effect of psychosocial stress on HIV pathogenesis during acute viral infection without sociobehavioral confounders inherent in human cohorts, we compared commonly measured parameters of HIV progression between singly (n = 35) and socially (n = 41) housed simian immunodeficiency virus (SIV)-infected pigtailed macaques (Macaca nemestrina).
resultsSingly housed macaques had a higher viral load in the plasma and cerebrospinal fluid and demonstrated greater CD4 T-cell declines and more CD4 and CD8 T-cell activation compared with socially housed macaques throughout acute SIV infection.
conclusionsThese data demonstrate that psychosocial stress directly impacts the pathogenesis of acute SIV infection and imply that it may act as an integral variable in the progression of HIV infection and potentially of other viral infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.