ArticleeLife2021
A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Identification of a functional DddX-like enzyme that catalyzes dimethylsulfoniopropionate cleavage in marine bacteria.Engineering microbiology · 2026Article
- Review
- Structural insights into bacterial dimethylsulfoniopropionate import by BCCT-family transporters.The EMBO journal · 2026Article
- Taxonomic composition and ecophysiology of resident bacteria associated with marine phytoplankton.Nature ecology & evolution · 2026Article
- Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria.The EMBO journal · 2026Article
- Predicted shifts in bacterial and algal contributions to DMSP and DMS dynamics during a coastal spring-summer bloom.The ISME journal · 2026Article
- Elucidation of dimethyl sulfide assimilation in soil bacteria expands the enzymatic landscape of terrestrial sulfur cycling.The ISME journal · 2026Article
- Metabolomic and flavoromic insights into the effects ofFrontiers in nutrition · 2026Article
- Mechanistic insights into the dimethylsulfoniopropionate synthesis enzyme BurB.Applied and environmental microbiology · 2025Article
- Cloning and expression of the dimethylsulfoniopropionate lyase geneCurrent research in microbial sciences · 2025Article
- Crystal structure of the 4-hydroxybutyryl-CoA synthetase (ADP-forming) from nitrosopumilus maritimus.Communications biology · 2024Article
- Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms.Nature microbiology · 2024Article
- Article
- DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.Nature microbiology · 2023Article
- Similar but different: Characterization ofScience advances · 2023Article
- The Diversity and Metabolism of Culturable Nitrate-Reducing Bacteria from the Photic Zone of the Western North Pacific Ocean.Microbial ecology · 2023Article
- Aerobic methylation of hydrogen sulfide to dimethylsulfide in diverse microorganisms and environments.The ISME journal · 2023Article
- Microbial Dimethylsulfoniopropionate Cycling in Deep Sediment of the Mariana Trench.Applied and environmental microbiology · 2023Article
- A new dimethylsulfoniopropionate lyase of the cupin superfamily in marine bacteria.Environmental microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dimethylsulfoniopropionate (DMSP) is an abundant and ubiquitous organosulfur molecule in marine environments with important roles in global sulfur and nutrient cycling. Diverse DMSP lyases in some algae, bacteria, and fungi cleave DMSP to yield gaseous dimethyl sulfide (DMS), an infochemical with important roles in atmospheric chemistry. Here, we identified a novel ATP-dependent DMSP lyase, DddX. DddX belongs to the acyl-CoA synthetase superfamily and is distinct from the eight other known DMSP lyases. DddX catalyses the conversion of DMSP to DMS via a two-step reaction: the ligation of DMSP with CoA to form the intermediate DMSP-CoA, which is then cleaved to DMS and acryloyl-CoA. The novel catalytic mechanism was elucidated by structural and biochemical analyses. DddX is found in several Alphaproteobacteria, Gammaproteobacteria, and Firmicutes, suggesting that this new DMSP lyase may play an overlooked role in DMSP/DMS cycles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.