Evidence map›Paper›PMID 33969849›Full record

ArticleJournal of materials chemistry. B2021

Smart scaffolds: shape memory polymers (SMPs) in tissue engineering.

Michaela R Pfau, Melissa A Grunlan

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  13. Structural Color Colloidal Photonic Crystals for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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  17. Journal of materials chemistry. B · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michaela R PfauDepartment of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA. mgrunlan@tamu.edu.
Melissa A GrunlanDepartment of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA. mgrunlan@tamu.edu and Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843, USA and Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-5428-0461

Funding

Bioactive, "Self-fitting" Shape Memory Polymer (SMP) Scaffolds to Treat Cranial Bone DefectsR01DE025886 · NIDCR · TEXAS ENGINEERING EXPERIMENT STATION · PI GRUNLAN, MELISSA · 2017 to 2020
$1.8M
NIDCR NIH HHS R01 DE025886
6 · The paper itself

Abstract

Smart scaffolds based on shape memory polymer (SMPs) have been increasingly studied in tissue engineering. The unique shape actuating ability of SMP scaffolds has been utilized to improve delivery and/or tissue defect filling. In this regard, these scaffolds may be self-deploying, self-expanding, or self-fitting. Smart scaffolds are generally thermoresponsive or hydroresponsive wherein shape recovery is driven by an increase in temperature or by hydration, respectively. Most smart scaffolds have been directed towards regenerating bone, cartilage, and cardiovascular tissues. A vast variety of smart scaffolds can be prepared with properties targeted for a specific tissue application. This breadth of smart scaffolds stems from the variety of compositions employed as well as the numerous methods used to fabricated scaffolds with the desired morphology. Smart scaffold compositions span across several distinct classes of SMPs, affording further tunability of properties using numerous approaches. Specifically, these SMPs include those based on physically cross-linked and chemically cross-linked networks and include widely studied shape memory polyurethanes (SMPUs). Various additives, ranging from nanoparticles to biologicals, have also been included to impart unique functionality to smart scaffolds. Thus, given their unique functionality and breadth of tunable properties, smart scaffolds have tremendous potential in tissue engineering.

Indexed as

Tissue EngineeringTissue ScaffoldsBiocompatible MaterialsBone RegenerationCardiovascular SystemCartilageHumansSmart MaterialsBiocompatible MaterialsSmart Materials

Identifiers

PMID33969849
PMCPMC8178240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.