Evidence map›Paper›PMID 33969697›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Vascular control of kidney epithelial transporters.

Matthew A Sparks, Emre Dilmen, Donna L Ralph, Fitra Rianto, Thien A Hoang, Alison Hollis, Edward J Diaz, Rishav Adhikari, Gabriel Chew, Enrico G Petretto and 3 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. The kidney stroma in development and disease.Nature reviews. Nephrology · 2025
    Review
  2. Genetic Deletion of ATInternational journal of molecular sciences · 2022
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Matthew A SparksDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.ORCID 0000-0003-2075-2691
Emre DilmenDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Donna L RalphDepartment of Physiology and Neuroscience, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Fitra RiantoDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.ORCID 0000-0002-6241-6816
Thien A HoangDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Alison HollisDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Edward J DiazDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Rishav AdhikariDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Gabriel ChewProgram in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore.
Enrico G PetrettoProgram in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore.
Susan B GurleyDivision of Nephrology and Hypertension, Oregon Health & Science University, Portland, Oregon.
Alicia A McDonoughDepartment of Physiology and Neuroscience, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID 0000-0002-0459-469X
Thomas M CoffmanDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Duke University · USDuke-NUS Medical School · SGUniversity of Southern California · USOregon Health & Science University · US

Funding

Renal Genomics CoreP30DK096493 · NIDDK · DUKE UNIVERSITY · PI FOSTER, MARY H., SVETKEY, LAURA P · 2012 to 2016
$5.9M
Sodium transporter regulation during hypertensionR01DK083785 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AURELIE EDWARDS, Alicia A. McDonough · 2011 to 2026
$5.8M
Actions of Angiotensin II Along the Nephron to Regulate Blood PressureR01DK098382 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GURLEY, SUSAN BAILEY · 2014 to 2025
$3.8M
Paracrine Control of Blood Pressure by Renal Intercalated CellsR01DK105049 · NIDDK · DUKE UNIVERSITY · PI COFFMAN, THOMAS M · 2015 to 2019
$1.8M
Renal sodium handling in hypertension: impact of age, sex, and dietary potassiumR56DK123780 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EDWARDS, AURELIE, MCDONOUGH, ALICIA A. · 2020 to 2020
$98k
AT1 Angiotensin Receptors in the Renal Circulation Control Blood PressureIK2BX002240 · VA · DURHAM VA MEDICAL CENTER · PI SPARKS, MATTHEW AARON · 2014 to 2018
–
BLRD VA IK2 BX002240HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30 DK-096493HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK083786HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK098382HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK105049Medical Research Council MC_U120097112NIDDK NIH HHS P30 DK096493NIDDK NIH HHS R01 DK083785NIDDK NIH HHS R01 DK098382NIDDK NIH HHS R01 DK105049NIDDK NIH HHS R56 DK123780U.S. Department of Veterans Affairs (VA) IK2BX002240
6 · The paper itself

Abstract

A major pathway in hypertension pathogenesis involves direct activation of ANG II type 1 (AT

Indexed as

AmilorideAngiotensin IIAnimalsEpithelial CellsEpithelial Sodium Channel BlockersFemaleFurosemideGene Expression RegulationGreen Fluorescent ProteinsHypertensionKidneyLuminescent ProteinsMaleMiceMice, Inbred StrainsMice, KnockoutAmilorideAngiotensin IIEpithelial Sodium Channel BlockersFurosemideGreen Fluorescent ProteinsLuminescent ProteinsReceptor, Angiotensin, Type 1Red Fluorescent ProteinSodiumSodium Potassium Chloride Symporter Inhibitorsamilorideangiotensinepithelial Na+ channelfurosemidehypertension

Identifiers

PMID33969697
PMCPMC8285646
OpenAlexW3163801207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.