Evidence map›Paper›PMID 33969350›Full record

ArticleJournal of the American College of Emergency Physicians open2021

Assessing COVID-19 pneumonia-Clinical extension and risk with point-of-care ultrasound: A multicenter, prospective, observational study.

Arthur W E Lieveld, Bram Kok, Kaoutar Azijli, Frederik H Schuit, Peter M van de Ven, Chris L de Korte, Robin Nijveldt, Frederik M A van den Heuvel, Bernd P Teunissen, Wouter Hoefsloot and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Lung ultrasound in predicting COVID-19 clinical outcomes: A prospective observational study.Journal of the American College of Emergency Physicians open · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Arthur W E LieveldSection General and Acute Internal Medicine Department of Internal Medicine Amsterdam Public Health Research Institute Amsterdam University Medical Center Amsterdam The Netherlands.
Bram KokSection Acute Internal Medicine, Department of Internal Medicine Radboud University Medical Center Nijmegen The Netherlands.
Kaoutar AzijliSection Emergency Medicine Emergency Department Amsterdam Public Health Research Institute, Amsterdam University Medical Center Amsterdam The Netherlands.
Frederik H SchuitSection General and Acute Internal Medicine Department of Internal Medicine Amsterdam Public Health Research Institute Amsterdam University Medical Center Amsterdam The Netherlands.
Peter M van de VenDepartment of Epidemiology and Data Science Amsterdam University Medical Center Amsterdam The Netherlands.
Chris L de KorteMedical UltraSound Imaging Center Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen The Netherlands.
Robin NijveldtDepartment of Cardiology Radboud University Medical Center Nijmegen The Netherlands.
Frederik M A van den HeuvelDepartment of Cardiology Radboud University Medical Center Nijmegen The Netherlands.
Bernd P TeunissenDepartment of Radiology & Nuclear Medicine Amsterdam University Medical Center Amsterdam The Netherlands.
Wouter HoefslootRadboudumc Center for Infectious Diseases Department of Pulmonary Diseases Radboud University Medical Center Nijmegen The Netherlands.
Prabath W B NanayakkaraSection General and Acute Internal Medicine Department of Internal Medicine Amsterdam Public Health Research Institute Amsterdam University Medical Center Amsterdam The Netherlands.
Frank H BoschSection Acute Internal Medicine, Department of Internal Medicine Radboud University Medical Center Nijmegen The Netherlands.
Radboud University Medical Center · NLRadboud University Nijmegen · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessing the extent of lung involvement is important for the triage and care of COVID-19 pneumonia. We sought to determine the utility of point-of-care ultrasound (POCUS) for characterizing lung involvement and, thereby, clinical risk determination in COVID-19 pneumonia.

methodsThis multicenter, prospective, observational study included patients with COVID-19 who received 12-zone lung ultrasound and chest computed tomography (CT) scanning in the emergency department (ED). We defined lung disease severity using the lung ultrasound score (LUS) and chest CT severity score (CTSS). We assessed the association between the LUS and poor outcome (ICU admission or 30-day all-cause mortality). We also assessed the association between the LUS and hospital length of stay. We examined the ability of the LUS to differentiate between disease severity groups. Lastly, we estimated the correlation between the LUS and CTSS and the interrater agreement for the LUS. We handled missing data by multiple imputation with chained equations and predictive mean matching.

resultsWe included 114 patients treated between March 19, 2020, and May 4, 2020. An LUS ≥12 was associated with a poor outcome within 30 days (hazard ratio [HR], 5.59; 95% confidence interval [CI], 1.26-24.80;

conclusionsWe showed that baseline lung ultrasound - is associated with poor outcomes, admission duration, and disease severity. The LUS also correlates well with CTSS. Point-of-care lung ultrasound may aid the risk stratification and triage of patients with COVID-19 at the ED.

Indexed as

30‐day mortalityCOVID‐19ICU admissionlung ultrasoundpneumoniapoint‐of‐care ultrasoundpoor outcome

Identifiers

PMID33969350
PMCPMC8087918
OpenAlexW3161430163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.