Evidence map›Paper›PMID 33969303›Full record

ArticleRegenerative medicine frontiers2019

Immuno-Isolating Dual Poly(ethylene glycol) Capsule Prevents Cancer Cells from Spreading Following Mouse Ovarian Tissue Auto-Transplantation.

James R Day, Anu David, Catherine Long, Grace G Bushnell, Teresa K Woodruff, Lonnie D Shea, Ariella Shikanov

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative medicine frontiers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

James R DayDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Anu DavidDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Catherine LongDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Grace G BushnellDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Teresa K WoodruffDepartment of Obstetrics and Gynecology, Northwestern University, Evanston, IL 60611, USA.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Ariella ShikanovDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · US

Funding

Project 3: Medically-based Protection of the Ovarian Reserve Against Anti-CancerP50HD076188 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2014 to 2017
$6.2M
Measuring Signaling Pathway Dynamics During Tissue Growth in HydrogelsR01CA214384 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JERUSS, JACQUELINE SARA, SHEA, LONNIE D · 2017 to 2021
$1.8M
Engineering an immuno-isolating hydrogel for restoring ovarian endocrine functionR01EB022033 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHIKANOV, ARIELLA · 2016 to 2019
$1.5M
Heterogeneity of early metastatic tumor cellsF31CA224982 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUSHNELL, GRACE GILMORE · 2018 to 2019
$56k
NCI NIH HHS F31 CA224982NCI NIH HHS R01 CA214384NIBIB NIH HHS R01 EB022033NICHD NIH HHS P50 HD076188
6 · The paper itself

Abstract

For female cancer survivors, premature ovarian insufficiency (POI) is a common complication of anticancer treatments. Ovarian tissue cryopreservation before treatment, followed by auto-transplantation after remission is a promising option to restore fertility and ovarian endocrine function. However, auto-transplantation is associated with the risk of re-introducing malignant cells harbored in the stroma of the ovarian autograft. To mitigate this risk, we investigated in this pilot study whether an immuno-isolating dual-layered poly(ethylene glycol)(PEG) capsule can retain cancer cells, while supporting folliculogenesis. The dual PEG capsule loaded with 1000 4T1 cancer cells retained 100% of the encapsulated cells

Indexed as

female cancer survivorsimmuno-isolationovarian tissue auto-transplantationpoly(ethylene glycol)

Identifiers

PMID33969303
PMCPMC8101948
OpenAlexW2973804447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.