Evidence map›Paper›PMID 33969287›Full record

ArticleCurrent research in immunology2021

Reduced A-to-I editing of endogenous Alu RNAs in lung after SARS-CoV-2 infection.

Philip S Crooke, John T Tossberg, Krislyn P Porter, Thomas M Aune

Open access · goldAbstract read
In one paragraph

Article in Current research in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Philip S CrookeDepartment of Mathematics, Vanderbilt University, Nashville, TN, 37212, USA.
John T TossbergDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37212, USA.
Krislyn P PorterDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37212, USA.
Thomas M AuneDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37212, USA.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (dsRNAs), as a result of inactivating mutations in

Indexed as

Alu RNAsA-to-I, adenosine-to-inosineA-to-I editingDouble-stranded RNA sensorsEEL, editing enriched locationIRs, inverted repeatsISGs, interferon-stimulated genesNHBE, normal human bronchial epithelial cellsRNA-seq, whole genome RNA-sequencingSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome coronavirus 2

Identifiers

PMID33969287
PMCPMC8084883
OpenAlexW3157643812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.