Evidence map›Paper›PMID 33969173›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity.

Zimu Wu, Robyn L Woods, Rory Wolfe, Elsdon Storey, Trevor T J Chong, Raj C Shah, Suzanne G Orchard, John J McNeil, Anne M Murray, Joanne Ryan and 1 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  13. Interpretable machine learning for precision cognitive aging.Frontiers in computational neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zimu WuSchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
Rory WolfeSchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
Elsdon StoreySchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
Trevor T J ChongTurner Institute for Brain and Mental Health Monash University Melbourne Australia.
Raj C ShahDepartment of Family Medicine and Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Suzanne G OrchardSchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
John J McNeilSchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
Anne M MurrayBerman Center for Outcomes and Clinical Research Minneapolis Minnesota USA.
Joanne RyanSchool of Public Health and Preventive Medicine Monash University Melbourne Australia.
ASPREE Investigator Group

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MURRAY, ANNE M · 2019 to 2023
$42.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
NIA NIH HHS P30 AG024824NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

introductionThis study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia.

methodsGenerally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories.

resultsFour to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psychomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories ( DISCUSSION: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

Indexed as

cognitive functiondementialongitudinalolder adultsprospective

Identifiers

PMID33969173
PMCPMC8088593

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.