Evidence map›Paper›PMID 33968916›Full record

ArticleFrontiers in bioengineering and biotechnology2021

An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the "Gold Standard" Bone Graft.

Pierre Tournier, Jérôme Guicheux, Arnaud Paré, Joëlle Veziers, Ana Barbeito, Raphaël Bardonnet, Pierre Corre, Valérie Geoffroy, Pierre Weiss, Alexis Gaudin

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Early clinical experience with a new supercritical COEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Observational
  3. Satisfactory long-term clinical and radiographic outcomes using supercritical COEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pierre TournierINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, ONIRIS, Université de Nantes, Nantes, France.
Jérôme GuicheuxINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, ONIRIS, Université de Nantes, Nantes, France.
Arnaud ParéINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, ONIRIS, Université de Nantes, Nantes, France.
Joëlle VeziersINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, ONIRIS, Université de Nantes, Nantes, France.
Ana BarbeitoBIOBank SAS, Lieusaint, France.
Raphaël BardonnetBIOBank SAS, Lieusaint, France.
Pierre CorreINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, ONIRIS, Université de Nantes, Nantes, France.
Valérie GeoffroyINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, ONIRIS, Université de Nantes, Nantes, France.
Pierre WeissINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, ONIRIS, Université de Nantes, Nantes, France.
Alexis GaudinINSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, CHU Nantes, ONIRIS, Université de Nantes, Nantes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous bone grafts (BGs) remain the reference grafting technique in various clinical contexts of bone grafting procedures despite their numerous peri- and post-operative limitations. The use of allogeneic bone is a viable option for overcoming these limitations, as it is reliable and it has been widely utilized in various forms for decades. However, the lack of versatility of conventional allogeneic BGs (e.g., blocks, powders) limits their potential for use with irregular or hard-to-reach bone defects. In this context, a ready- and easy-to-use partially demineralized allogeneic BG in a paste form has been developed, with the aim of facilitating such bone grafting procedures. The regenerative properties of this bone paste (BP) was assessed and compared to that of a syngeneic BG in a pre-clinical model of intramembranous bone healing in critical size defects in rat calvaria. The microcomputed tridimensional quantifications and the histological observations at 7 weeks after the implantation revealed that the

Indexed as

allogeneic bonebone graftbone healingpre-clinicalrat calvaria

Identifiers

PMID33968916
PMCPMC8098662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.