ArticleFrontiers in oncology2021
Lung Stereotactic Body Radiotherapy (SBRT) Using Spot-Scanning Proton Arc (SPArc) Therapy: A Feasibility Study.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Particle Arc Therapy in Cancer Radiotherapy: A Scoping Review of Feasibility and Dosimetric Evidence.Cancers · 2026Review
- Mid-range arc therapy for efficient and RBE-robust proton treatment.Physics in medicine and biology · 2026Article
- Advancing proton therapy: Dosimetric superiority of proton arc therapy over IMPT in esophageal cancer treatment.Journal of applied clinical medical physics · 2026Article
- Design an open-access dynamic spot-scanning proton arc system controller for quantitative and comprehensive investigation of delivery efficiency.Medical physics · 2026Article
- Integrating spot-scanning proton arc therapy with functional avoidance strategies to reduce pulmonary toxicity.Physics and imaging in radiation oncology · 2025Article
- Shoot-through layers in upright proton arcs unlock advantages in plan quality and range verification.Medical physics · 2025Article
- Exploring the potential benefits of multi-field IMPT for stage I NSCLC SBRT: An in silico dosimetric comparison to IMRT and CyberKnife.Precision radiation oncology · 2025Article
- First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment.International journal of particle therapy · 2025Article
- Feasibility of Utilizing Spot-Scanning Proton Arc (SPArc) for Whole-Lung Irradiation: A Case Report.International journal of particle therapy · 2025Article
- Dosimetric comparison of intensity-modulated proton therapy and proton arc therapy for pediatric ependymoma.Acta oncologica (Stockholm, Sweden) · 2025Article
- Rotationally Intensified Proton Lattice: A Novel Lattice Technique Using Spot-Scanning Proton Arc Therapy.Advances in radiation oncology · 2024Article
- FLASH instead of proton arc therapy is a more promising advancement for the next generation proton radiotherapy.Journal of applied clinical medical physics · 2023Article
- Risk of second primary cancer from proton arc therapy of pediatric brain tumors.Physics and imaging in radiation oncology · 2023Article
- Article
- Prognostic significance of SPARC expression in non-small cell lung cancer: A meta-analysis and bioinformatics analysis.Oncology letters · 2022Article
- It is beneficial to invest resources to implement proton intracranial SRS.Journal of applied clinical medical physics · 2022Article
- Redefine the Role of Spot-Scanning Proton Beam Therapy for the Single Brain Metastasis Stereotactic Radiosurgery.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe developed a 4D interplay effect model to quantitatively evaluate breathing-induced interplay effects and assess the feasibility of utilizing spot-scanning proton arc (SPArc) therapy for hypo-fractionated lung stereotactic body radiotherapy (SBRT). The model was then validated by retrospective application to clinical cases. MATERIALS AND
methodsA digital lung 4DCT phantoms was used to mimic targets in diameter of 3cm with breathing motion amplitudes: 5, 10, 15, and 20 mm, respectively. Two planning groups based on robust optimization were generated: (1) Two-field Intensity Modulated Proton Therapy (IMPT) plans and (2) SPArc plans
resultTarget dose were degraded as the tumor motion amplitude increased. The 4D interplay effect phantom model indicated that motion mitigation effectiveness using SPArc was about five times of IMPT
conclusionSPArc effectively mitigated the interplay effect for proton lung SBRT compared to IMPT with repainting and was associated with normal tissue sparing. This technology may make delivery of proton SBRT more technically feasible and less complex with fewer concerns over underdosing the target compared to other proton therapy techniques.
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