ArticleGland surgery2021
The systemic immune-inflammation index-based model is an effective biomarker on predicting central lymph node metastasis in clinically nodal-negative papillary thyroid carcinoma.
Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Role of nutritional (PNI, CONUT) and inflammatory indices (SII) in predicting lymph node metastasis and prognosis of thyroid cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives.Frontiers in oncology · 2025Pooled it
- The Role of Preoperative Radiological, Cytological, and Systemic Inflammatory Markers in Predicting Incidental Papillary Microcarcinoma in Patients with Multinodular Goiter: A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- An interpretable machine learning model for predicting central lymph node metastasis in cN0 T1-T2 papillary thyroid carcinoma: a retrospective study.Frontiers in endocrinology · 2026Article
- Development and validation of an interpretable machine learning model for predicting central lymph node metastasis in papillary thyroid cancer.Frontiers in oncology · 2026Article
- Diagnostic and predictive value of the hemoglobin-albumin-lymphocyte-platelet score in thyroid nodules: A retrospective analysis of 521 patients.Northern clinics of Istanbul · 2026Article
- Systemic inflammatory indices comprising monocytes provide a clinical significance for thyroid cancer identification.Scientific reports · 2025Article
- Multimodal ultrasound to predict central cervical lymph node metastasis in clinically lymph node-negative differentiated thyroid carcinomas: a two-center retrospective study.Gland surgery · 2025Article
- PROS1-MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Single-cell perspective on the Monocyte-to-HDL cholesterol ratio as a metastasis biomarker in papillary thyroid cancer.BMC cancer · 2025Article
- Article
- An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer.Frontiers in molecular biosciences · 2025Article
- Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) Before Treatment as the Predictive Indicators for Bone Metastasis in Prostate Cancer Patients.International journal of general medicine · 2025Article
- Laboratory parameters-based logistic regression models for rapid screening of thyroid nodules.Gland surgery · 2024Article
- Evaluation of systemic inflammation markers in patients with Hashimoto's thyroiditis.The Journal of international medical research · 2024Article
- Association between blood inflammatory indicators and prognosis of papillary thyroid carcinoma: a narrative review.Gland surgery · 2024Review
- The Association of Pretreatment Systemic Immune Inflammatory Response Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR) with Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma.International journal of general medicine · 2024Article
- Article
- Development and validation of the nomogram based on ultrasound, thyroid stimulating hormone, and inflammatory marker in papillary thyroid carcinoma: a case-control study.Translational cancer research · 2023Article
- A novel proportional index to differentiate between demographically and clinically matched cases with papillary thyroid carcinoma or non-cancerous nodule: PLR-to-PDW ratio.American journal of translational research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high proportion of papillary thyroid carcinoma (PTC) patients are involved in central lymph node metastasis (CLNM) with preoperative imaging examinations showing clinically nodal-negative (cN0). Meanwhile, many inflammatory biomarkers are also proven as effective factors to predict the outcomes of cancer patients and tumor progression. Thus, the values of these factors are investigated to help detecting CLNM in cN0 PTC patients.
methods406 cN0 PTC patients who underwent curative surgery were retrospectively analyzed. CLNM was determined by histopathological examination following the thyroidectomy. Multiple inflammatory biomarkers were comprehensively researched.
resultsA total of 406 consecutive patients were eventually included. The univariate and multivariate analyses revealed that age (OR: 0.924, 95% CI: 0.909, 0.940), gender (OR: 1.781, 95% CI: 1.060, 2.993), location of tumors (OR: 2.229, 95% CI: 1.228, 4.046) and level of systemic immune-inflammation index (SII) (OR: 1.005, 95% CI: 1.004, 1.006) were independently associated with CLNM in cN0 PTC patients, and the SII-based predictive model was constructed using these four factors. Receiver operating characteristic (ROC) curves showed significant results of the SII-based predictive model in PTC cohort with area under curve (AUC) as 0.814 (95% CI: 0.771-0.857) and in PTMC subgroup with AUC as 0.803 (95% CI: 0.752-0.854).
conclusionsThe SII-based model can effectively help predicting CLNM in both cN0 PTC patients and cN0 PTMC patients.
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