Evidence map›Paper›PMID 33968346›Full record

ArticleGastroenterology and hepatology from bed to bench2021

Gastric amyloidosis in a patient with dysphagia.

Sami Ghazaleh, Anay Hindupur, Christian Nehme, Yasmin Khader, Marcel Ghanim, Taha Sheikh, Tarik Alhmoud

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in Gastroenterology and hepatology from bed to bench, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sami GhazalehDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.
Anay HindupurDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.
Christian NehmeDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.
Yasmin KhaderDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.
Marcel GhanimDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.
Taha SheikhDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.
Tarik AlhmoudDepartment of Gastroenterology, ProMedica Toledo Hospital, Toledo, Ohio, USA.
University of Toledo Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysphagia is a symptom with a broad differential diagnosis. Usually, the etiology of dysphagia is benign, but it is essential to rule out serious causes. It is also critical to think outside the box when the etiology is not obvious. Herein, we describe a case of multiple myeloma that initially presented with dysphagia. An 81-year-old male patient presented with dysphagia to solid food associated with anorexia and weight loss of 22 kg over the last 6 months. The patient looked chronically ill and cachectic. Upper endoscopy showed patchy erythema in the gastric antrum. Gastric biopsy was consistent with gastric amyloidosis. Although serum and urine protein electrophoresis did not show a monoclonal (M) band, immunofixation did show elevated free kappa light chains and elevated free Kappa/Lambda ratio. Bone marrow biopsy was consistent with multiple myeloma. Although gastrointestinal involvement is common in amyloidosis, it is unusual for amyloidosis to initially present in the gastrointestinal tract. Identification and treatment of the underlying condition, e.g., multiple myeloma, can lead to regression of gastrointestinal amyloidosis.

Indexed as

AmyloidosisDysphagiaMalignancyMultiple myelomaPlasma cell disorders

Identifiers

PMID33968346
PMCPMC8101516
OpenAlexW3154757714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.