Evidence map›Paper›PMID 33968296›Full record

ArticleOxidative medicine and cellular longevity2021

Plasma Small Extracellular Vesicle-Carried miRNA-501-5p Promotes Vascular Smooth Muscle Cell Phenotypic Modulation-Mediated In-Stent Restenosis.

Xiao-Fei Gao, Zhi-Mei Wang, Ai-Qun Chen, Feng Wang, Shuai Luo, Yue Gu, Xiang-Quan Kong, Guang-Feng Zuo, Xiao-Min Jiang, Guan-Wen Ding and 4 more

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Diabetes and restenosis.Cardiovascular diabetology · 2022
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Xiao-Fei GaoDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhi-Mei WangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ai-Qun ChenDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Feng WangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Shuai LuoDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yue GuDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiang-Quan KongDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Guang-Feng ZuoDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiao-Min JiangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Guan-Wen DingNanjing Foreign Language School, Nanjing, China.
Yan ChenDepartment of Neurology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China.
Zhen GeDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jun-Jie ZhangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-2710-8516
Shao-Liang ChenDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-3887-952X
Nanjing Medical University · CNNanjing Drum Tower Hospital · CNNanjing Foreign Language School · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular smooth muscle cell (VSMC) phenotypic modulation plays an important role in the occurrence and development of in-stent restenosis (ISR), the underlying mechanism of which remains a key issue needing to be urgently addressed. This study is designed to investigate the role of plasma small extracellular vesicles (sEV) in VSMC phenotypic modulation. sEV were isolated from the plasma of patients with ISR (ISR-sEV) or not (Ctl-sEV) 1 year after coronary stent implantation using differential ultracentrifugation. Plasma sEV in ISR patients are elevated markedly and decrease the expression of VSMC contractile markers

Indexed as

AnimalsCoronary RestenosisExtracellular VesiclesHumansMaleMicroRNAsMuscle, Smooth, VascularPhenotypeRatsRats, Sprague-DawleyMicroRNAsMIRN5100 microRNA, human

Identifiers

PMID33968296
PMCPMC8084657
OpenAlexW3152574449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.