ArticleExperimental and therapeutic medicine2021
Life-threatening complications of hyperemesis gravidarum.
Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Pregnancy-related disorders: molecular mechanisms and management.Molecular biomedicine · 2026Review
- Spontaneous pneumomediastinum, pneumorrhachis, and subcutaneous emphysema secondary to hyperemesis gravidarum: A case report.Case reports in women's health · 2026Article
- Pre-hospital healthcare for hyperemesis gravidarum: a cross-sectional analysis of baseline data from the SUKK-P study.BMC pregnancy and childbirth · 2026Article
- Liver Conditions Specific to Pregnancy: Optimizing Management and Outcomes.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Review
- Liver function disorders in pregnancy: physiology or pathology?Przeglad gastroenterologiczny · 2026Review
- Advancing the women's health strategy: a policy lab aimed at improving effective management of hyperemesis gravidarum.Health research policy and systems · 2025Article
- A scoping review of models of care and services for nausea and vomiting in pregnancy and hyperemesis gravidarum.BMC pregnancy and childbirth · 2025Article
- The impact and management of hyperemesis gravidarum: Current and future perspectives.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- How are hospitals in England, Scotland and Wales caring for women with nausea and vomiting in pregnancy: a national service evaluation.BMC health services research · 2025Article
- Wernicke encephalopathy in pregnancy associated with hyperemesis gravidarum: a case report.BMC pregnancy and childbirth · 2025Article
- Elevated B-type natriuretic peptide levels in pregnant women with hyperemesis gravidarum: a biomarker of cardiac stress?Revista da Associacao Medica Brasileira (1992) · 2025Article
- Electrolyte imbalance and liver function test abnormalities among pregnant women with hyperemesis gravidarum at Wag-himra zone public hospitals, Northeast Ethiopia, 2023: a comparative cross-sectional study.Frontiers in medicine · 2024Article
- The hyperemesis gravidarum and pulmonary embolism: A case report and review of literature.Qatar medical journal · 2024Article
- An Interesting Presentation of Pneumomediastinum Secondary to Hyperemesis Gravidarum in the Second Trimester.Cureus · 2023Article
- Risk of Cardiovascular Disease in Women With a History of Hyperemesis Gravidarum, With and Without Preeclampsia.Journal of the American Heart Association · 2023Article
- Assessment of management approaches for hyperemesis gravidarum and nausea and vomiting of pregnancy: a retrospective questionnaire analysis.BMC pregnancy and childbirth · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperemesis gravidarum (HG) refers to severe nausea and emesis noted during pregnancy. However, no consensus exists on the specific diagnostic criteria that can be used for this condition. The aim of the present systematic review was to summarize the available evidence regarding the severe complications observed during HG with a heightened risk of fatality. A systematic search was conducted on PubMed, Cochrane Library, EMBASE and WILEY databases for the relevant publications regarding the severe and life-threatening complications of HG. The search terms were as follows: '(Hyperemesis gravidarum)' AND ('complications' OR 'severe' OR 'adverse pregnancy outcomes' OR 'stroke' OR 'seizures' OR 'Wernicke's encephalopathy' OR 'arrhythmias' OR 'pneumomediastinum' OR 'coagulopathy' OR 'electrolytic imbalance'). Abstracts, conference presentations, letters to the editor, studies written in languages other than English and editorials were all excluded. This search identified 43 studies analyzing life-threatening complications of HG, of which 11, seven, eight and 17 articles analyzed neurological, cardiovascular, thoracic and systemic complications, respectively. Reports on life-threatening complications were exceptionally rare in HG. The most frequent severe complications noted were Wernicke's encephalopathy, electrolyte imbalance and vitamin K deficiency. The low mortality rate for patients with HG over the last decade could be explained by the high efficiency of modern therapy, and the precise management of every complication according to current guidelines.
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