Evidence map›Paper›PMID 33968075›Full record

ArticleFrontiers in immunology2021

Allyl Isothiocyanate: A TAS2R38 Receptor-Dependent Immune Modulator at the Interface Between Personalized Medicine and Nutrition.

Hoai T T Tran, Rebecca Stetter, Corinna Herz, Jenny Spöttel, Mareike Krell, Franziska S Hanschen, Monika Schreiner, Sascha Rohn, Maik Behrens, Evelyn Lamy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Can trigeminal sensations impact saltiness perception? A mini-review.Journal of the science of food and agriculture · 2026
    Review
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  11. Phytochemicals and Inflammation: Is Bitter Better?Plants (Basel, Switzerland) · 2022
    Article
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  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Chemoinformatics View on Bitter Taste Receptor Agonists in Food.Journal of agricultural and food chemistry · 2021
    Article
  19. Bitter taste receptors: Genes, evolution and health.Evolution, medicine, and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Hoai T T TranMolecular Preventive Medicine, University Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.
Rebecca StetterMolecular Preventive Medicine, University Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.
Corinna HerzMolecular Preventive Medicine, University Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.
Jenny SpöttelInstitute of Food Technology and Food Chemistry, Technical University of Berlin, Berlin, Germany.
Mareike KrellInstitute of Food Technology and Food Chemistry, Technical University of Berlin, Berlin, Germany.
Franziska S HanschenPlant Quality and Food Security, Leibniz Institute of Vegetable and Ornamental Crops, Großbeeren, Germany.
Monika SchreinerPlant Quality and Food Security, Leibniz Institute of Vegetable and Ornamental Crops, Großbeeren, Germany.
Sascha RohnInstitute of Food Technology and Food Chemistry, Technical University of Berlin, Berlin, Germany.
Maik BehrensSection II: Metabolic Function, Chemoreception & Biosignals, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Freising, Germany.
Evelyn LamyMolecular Preventive Medicine, University Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.
Technische Universität Berlin · DEUniversity Medical Center Freiburg · DELeibniz Institute of Vegetable and Ornamental Crops · DELeibniz-Institute for Food Systems Biology at the Technical University of Munich · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding individual responses to nutrition and medicine is of growing interest and importance. There is evidence that differences in bitter taste receptor (TAS2R) genes which give rise to two frequent haplotypes, TAS2R38-PAV (functional) and TAS2R38-AVI (non-functional), may impact inter-individual differences in health status. We here analyzed the relevance of the TAS2R38 receptor in the regulation of the human immune response using the TAS2R38 agonist allyl isothiocyanate (AITC) from

Indexed as

Adaptive ImmunityAdultCalcium SignalingCells, CulturedDietEscherichia coli K12FemaleHumansImmunity, InnateImmunologic FactorsIsothiocyanatesLeukocytesMaleMicrobial ViabilityMitogen-Activated Protein KinasesPhosphatidylinositol 3-Kinaseallyl isothiocyanateImmunologic FactorsIsothiocyanatesMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledTaste Receptors, Type 2BrassicaceaeBrassica plantshuman bitter taste receptor (TAS2R)isothiocyanatespersonalized (precision) nutritionprecision healthprecision medicineTAS2R38

Identifiers

PMID33968075
PMCPMC8103899
OpenAlexW3155288483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.