Evidence map›Paper›PMID 33968070›Full record

ArticleFrontiers in immunology2021

Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells.

Katharina Rindler, Wolfgang M Bauer, Constanze Jonak, Matthias Wielscher, Lisa E Shaw, Thomas B Rojahn, Felix M Thaler, Stefanie Porkert, Ingrid Simonitsch-Klupp, Wolfgang Weninger and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. CD5 Expression in CTCL and Its Implications for Anti-CD5 CAR T-Cell Therapy.International journal of molecular sciences · 2025
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  19. JID innovations : skin science from molecules to population health · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Katharina RindlerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Wolfgang M BauerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Constanze JonakDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Matthias WielscherDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Lisa E ShawDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Thomas B RojahnDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Felix M ThalerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Stefanie PorkertDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Ingrid Simonitsch-KluppDepartment of Pathology, Medical University of Vienna, Vienna, Austria.
Wolfgang WeningerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Marius E MayerhoeferDivision of General and Pediatric Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Matthias FarlikDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Patrick M BrunnerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · AT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. While initially restricted to the skin, malignant cells can appear in blood, bone marrow and secondary lymphoid organs in later disease stages. However, only little is known about phenotypic and functional properties of malignant T cells in relationship to tissue environments over the course of disease progression. We thus profiled the tumor micromilieu in skin, blood and lymph node in a patient with advanced MF using single-cell RNA sequencing combined with V-D-J T-cell receptor sequencing. In skin, we identified clonally expanded T-cells with characteristic features of tissue-resident memory T-cells (T

Indexed as

AgedAntigens, CDAntigens, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansImmunologic MemoryLymph NodesMycosis FungoidesNeoplastic Stem CellsSequence Analysis, RNASkinSkin NeoplasmsT-LymphocytesTumor MicroenvironmentAntigens, CDAntigens, Neoplasmcentral memory T cellscutaneous T-cell lymphoma (CTCL)mycosis fungoidessingle-cell RNA sequencingtissue resident memory T cells

Identifiers

PMID33968070
PMCPMC8097053
OpenAlexW3155260164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.