Evidence map›Paper›PMID 33968028›Full record

ArticleFrontiers in immunology2021

Host-Specific Serum Factors Control the Development and Survival of

Anisuzzaman, Sören Frahm, Ulrich Fabien Prodjinotho, Sonakshi Bhattacharjee, Admar Verschoor, Clarissa Prazeres da Costa

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  9. Review
  10. DistinctPathogens (Basel, Switzerland) · 2021
    Article
  11. The Transcriptome ofFrontiers in tropical diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

AnisuzzamanInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Sören FrahmInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Ulrich Fabien ProdjinothoInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Sonakshi BhattacharjeeInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Admar VerschoorDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Clarissa Prazeres da CostaInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Institute of Medical Microbiology and Hygiene · DETechnical University of Munich · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of Materials and Methods: Using our recently developed novel serum- and cell-free Results: In contrast to sera from humans and a broad variety of mammalian species, serum from mice, surprisingly, killed parasites already at skin stage Conclusion: This study reveals that not yet identified heat-labile serum factors are major selective determinants of the host-specificity of schistosomiasis, by directly controlling schistosomal development and survival.

Indexed as

AnimalsComplement C1qComplement C3Complement C4Complement System ProteinsDisease Models, AnimalFemaleHost-Parasite InteractionsHumansImmunoglobulin MMacaca mulattaMaleMiceMice, Inbred C57BLMice, KnockoutSchistosoma mansoniC3 protein, mouseC4b protein, mouseComplement C1qComplement C3Complement C4Complement System ProteinsImmunoglobulin Mantibodiescomplement systemhost serumhost specificitynewly transformed schistosomulaschistomicidal activitySchistosoma mansoni

Identifiers

PMID33968028
PMCPMC8103320
OpenAlexW3160270817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.