Evidence map›Paper›PMID 33967787›Full record

ArticleFrontiers in pharmacology2021

Association of 5-Hydroxytryptamine 3 Receptor Antagonists With the Prognosis of Liver Failure.

Yuting Chen, Jingkang Sun, Xiude Fan, Xiaoyun Wang, Lu Zeng, Xiaoge Zhang, Kun Zhang, Na Li, Qunying Han, Zhengwen Liu

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Serotonin in the regulation of systemic energy metabolism.Journal of diabetes investigation · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuting ChenDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jingkang SunDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiude FanDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaoyun WangDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Lu ZengDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaoge ZhangDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Kun ZhangDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Na LiDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Qunying HanDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zhengwen LiuDepartment of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver failure is a severe clinical syndrome with high mortality. 5-Hydroxytryptamine 3 receptor antagonists (5-HT3RAs) can reduce liver damage in animal models. We investigated whether 5-HT3RAs may improve the prognosis of liver failure. We analyzed the 28 and 90 days mortality of liver failure patients in relation to the use of 5-HT3RAs using data from a tertiary hospital in northwest China. According to the use of 5-HT3RAs, 419 patients with liver failure (46 acute, 93 sub-acute, 44 chronic, 236 acute on chronic) were divided into 5-HT3RA group (

Indexed as

5-hydroxytryptamine 3 receptor antagonistliver failureprognosisshort-term survivaltreatment

Identifiers

PMID33967787
PMCPMC8100675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.